Table 2.
Summary of meta-analysis of association of TAP1 I333V gene polymorphism and T1DM
| Genetic model | Pooled OR (95% CI) | P value | Literature number | T1DM size | Control size | Pheterogeneity (I2%) |
|---|---|---|---|---|---|---|
| Allelic genetic model | 1.35 (1.08–1.68) | 0.007* | 13 | 1140 | 1106 | 0.04* (44.4) |
| Subgroup 1: before 1995 | 1.26 (0.90–1.75) | 0.17 | 7 | 719 | 605 | 0.04* (53.7) |
| Subgroup 2: after 1996 | 1.39 (1.11–1.74) | 0.004* | 6 | 421 | 501 | 0.13 (40.8) |
| Recessive genetic model | 1.384 (0.743–2.579) | 0.306 | 13 | 1140 | 1106 | 0.202 (23.9) |
| Dominant genetic model | 1.462 (1.094–1.955) | 0.010* | 13 | 1140 | 1106 | 0.007* (55.9) |
| Subgroup 1: IV1 < 30 | 1.289 (0.781–2.126) | 0.320 | 7 | 431 | 384 | 0.034* (56.1) |
| Subgroup 2: IV1 > 30 | 1.620 (1.143–2.296) | 0.007* | 6 | 709 | 722 | 0.041* (56.9) |
| Homo genetic model | 1.725 (1.082–2.752) | 0.022* | 13 | 1140 | 1106 | 0.324 (12.0) |
| Hetero genetic model | 1.430 (1.048–1.951) | 0.024* | 13 | 1140 | 1106 | 0.004* (58.4) |
| Subgroup 1:II1 < 40 | 2.183 (1.148–4.151) | 0.017* | 6 | 254 | 283 | 0.037* (57.8) |
| Subgroup 2: II1 ≥ 40 | 1.191 (0.963–1.472) | 0.106 | 7 | 886 | 823 | 0.190 (31.2) |
| Additive genetic model | 1.348 (1.084–1.676) | 0.007* | 13 | 1140 | 1106 | 0.043 (44.4) |
| Subgroup 1:II1 < 40 | 1.867 (1.361–2.561) | <0.001* | 6 | 254 | 283 | 0.262 (22.8) |
| Subgroup 2: II1 ≥ 40 | 1.218 (1.023–1.450) | 0.027* | 7 | 886 | 823 | 0.147 (36.8) |
*
P < 0.05. T1DM: type 1 diabetes mellitus; CI: confidence interval; OR: odds ratio; T1DM size: the total number of T1DM cases; control size: the total number of control group; homo genetic model: homozygous genetic model; hetero genetic model: heterozygous genetic model.