Table 3.

Summary of meta-analysis of association of TAP1 I333V gene polymorphism and T1DM stratified by ethnicities

Genetic model	Pooled OR (95% CI)	P value	Study number	T1DM size	Control size	Pheterogeneity (I2%)
Allelic genetic model	1.35 (1.08–1.68)	0.007*	13	1140	1106	0.04* (44.4)
Caucasian subgroup	1.30 (1.09–1.55)	0.004*	8	845	760	0.09 (43.3)
Asian subgroup	1.69 (0.86–3.34)	0.13	4	203	229	0.04* (64.2)
African subgroup	1.35 (0.83–2.20)	0.23	1	92	117	NA
Recessive genetic model	1.384 (0.743–2.579)	0.306	13	1140	1106	0.202 (23.9)
Caucasian subgroup	1.643 (0.971–2.780)	0.064	8	845	760	0.301 (16.4)
Asian subgroup	0.928 (0.222–3.873)	0.918	4	203	229	0.071 (57.3)
African subgroup	0.900 (0.578–1.399)	0.639	1	92	117	NA
Dominant genetic model	1.462 (1.094–1.955)	0.010*	13	1140	1106	0.007* (55.9)
Caucasian subgroup	1.330 (1.079–1.640)	0.008*	8	845	760	0.074 (45.8)
Asian subgroup	2.133 (0.815–5.583)	0.123	4	203	229	0.007 (75.0)
African subgroup	1.399 (0.792–2.470)	0.248	1	92	117	NA
Homozygous genetic model	1.725 (1.082–2.752)	0.022*	13	1140	1106	0.324 (12.0)
Caucasian subgroup	1.854 (1.082–3.176)	0.025*	8	845	760	0.349 (10.5)
Asian subgroup	1.235 (0.293–5.211)	0.773	4	203	229	0.129 (47.1)
African subgroup	3.136 (0.509–19.315)	0.218	1	92	117	NA
Heterzygous genetic model	1.430 (1.048–1.951)	0.024*	13	1140	1106	0.004* (58.4)
Caucasian subgroup	1.351 (0.889–2.054)	0.029*	8	845	760	0.081 (44.7)
Asian subgroup	2.141 (0.733–6.248)	0.164	4	203	229	0.004* (77.2)
African subgroup	1.975 (1.119–3.486)	0.019*	1	92	117	NA
Additive genetic model	1.348 (1.084–1.676)	0.007*	13	1140	1106	0.043* (44.4)
Caucasian subgroup	1.297 (1.088–1.548)	0.004*	8	845	760	0.09 (43.3)
Asian subgroup	1.614 (1.095–2.378)	0.015*	4	203	229	0.044* (62.9)
African subgroup	1.347 (0.827–2.196)	0.232	1	92	117	NA

NA: not applicable.

^*P < 0.05.