Skip to main content
. 2014 Apr 23;23(17):4686–4692. doi: 10.1093/hmg/ddu188

Figure 4.

Figure 4.

Neuronal complex I knockdown. (A) Selective knockdown of ND75 in neurons produces normal brain histology (left) and morphologically normal mitochondria (right). Scale bars are 20 µm in the H&E section and 5 μm in the immunostained section. Flies are 10 days old. (B) Kaplan–Meyer curves show significantly truncated lifespan with neuronal-selective ND75 knockdown animals. N = 300 per genotype; P < 0.001, log rank test. (C) Climbing assays show significant motor dysfunction in knockdown animals at 5 days. N = 60 per genotype. *P < 0.001, Student's t-test. Driver is elav-GAL4; control is elav-GAL4/+.