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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Breast Cancer Res Treat. 2014 Jun 12;146(2):259–272. doi: 10.1007/s10549-014-3014-7

Fig. 4.

Fig. 4

The combination of entinostat and lapatinib effectively suppressed tumor growth in breast cancer xenograft model. Cells (1×107 for BT474 or 2×106 for SUM190) in 50% Matrigel solution were transplanted into the mammary fat pads of 8 female nude mice per group. a BT474. b SUM190. Treatment started on day 18 after tumor cell implantation. The administered volume was 0.2 ml/30 g mouse body weight. Treatment was continued for 70 days for the BT474 group, and 25 days for the SUM190 group. IHC staining represents quantification of KI-67-positive cells in tumor tissue samples from each treatment group. Graphs and statistical significance were evaluated by an ANOVA using GraphPad Prism software. Error bars, standard deviation; magnification, ** p <0.01, *** p <0.001, ×20; scale bar, 50 μm.