Table 1.
Genes associated to tobacco use disorder selected from Gene2Mesh and Ingenuity
| Gene | Gene function | Gene2Mesh | Ingenuity |
|---|---|---|---|
|
CHAT |
Nicotinic receptor |
X |
|
|
CHRNA1 |
Nicotinic receptor |
|
X |
|
CHRNA2 |
Nicotinic receptor |
|
X |
|
CHRNA3 |
Nicotinic receptor |
X |
X |
|
CHRNA4 |
Nicotinic receptor |
X |
X |
|
CHRNA5 |
Nicotinic receptor |
X |
X |
|
CHRNA6 |
Nicotinic receptor |
|
X |
|
CHRNA7 |
Nicotinic receptor |
|
X |
|
CHRNA9 |
Nicotinic receptor |
|
X |
|
CHRNA10 |
Nicotinic receptor |
|
X |
|
CHRNB1 |
Nicotinic receptor |
|
X |
|
CHRNB2 |
Nicotinic receptor |
|
X |
|
CHRNB3 |
Nicotinic receptor |
|
X |
|
CHRNB4 |
Nicotinic receptor |
|
X |
|
CHRND |
Nicotinic receptor |
|
X |
|
CHRNE |
Nicotinic receptor |
|
X |
|
CHRNG |
Nicotinic receptor |
|
X |
|
COMT |
Dopamine |
X |
|
|
CYP2A6 |
Nicotine metabolism |
X |
|
|
DDC |
Dopamine |
X |
X |
|
DRD2 |
Dopamine |
X |
|
|
GABBR2 |
GABA |
|
X |
|
GABRA2 |
GABA |
X |
|
|
GABRA4 |
GABA |
X |
|
|
NRXN1 |
Neurexin |
|
X |
|
OPRD1 |
Opioid receptor |
|
X |
|
OPRM1 |
Opioid receptor |
|
X |
|
OPRK1 |
Opioid receptor |
|
X |
|
SIGMAR1 |
Non-opioid receptor |
|
X |
|
SLC6A3 |
Dopamine |
X |
X |
|
SLC6A4 |
Serotonin |
X |
X |
| TPH1 | Serotonin | X |
Selected genes are represented by X; GABA, Gamma-aminobutyric acid.