Fig. 2. Sleep, Fatigue and Depressive symptoms.
(mean+SE). BC= breast cancer patients, NC= cancer-free controls. Baseline = before the start of chemotherapy, Cycle-4 = at the end of cycle 4 chemotherapy, 1-Year = 1 year after the start of chemotherapy. Age and BMI were adjusted in the mixed model.
Fig. 2a. PSQI (Pittsburgh Sleep Quality Index, higher score indicates poorer sleep quality): Between groups (group effect p<0.0001): Baseline p=0.011; Cycle-4 p<0.0001; Year-1 p=0.020. Within BC group (time effect p=0.0003): changes form Baseline to Cycle-4 p=0.030; from Cycle-4 to Year-1 p=0.0018. No significant within-group changes for NC. Group-x-time interaction p=0.0030.
Fig. 2b: MFSI-SF (Multidimensional Fatigue Symptom Inventory-Short Form, higher score indicates more fatigue): Between groups (group effect p<0.0001): Baseline p=0.0019; Cycle-4 p<0.0001; Year-1 p=0.0091. Within BC group (time effect p<0.0001): changes from Baseline to Cycle-4 p=0.0031; from Cycle-4 to 1-Year p<0.0001. No significant within-group changes for NC. Group-x-time interaction p=0.0097.
Fig. 2c: CES-D (Center of Epidemiological Studies-Depression, higher score indicates more depressive symptoms): Between groups (group effect p<0.0001): Baseline p=0.0003; Cycle-4 p<0.0001; Year-1 p=0.039. Within BC group (time effect p<0.0001): changes from Baseline to Cycle-4 p=0.0087; from Cycle-4 to 1-Year p<0.0001; from Baseline to 1-Year p=0.037. No significant within-group changes for NC. Group-x-time interaction p=0.0093.