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. Author manuscript; available in PMC: 2015 Aug 15.
Published in final edited form as: J Immunol. 2014 Jul 14;193(4):1799–1811. doi: 10.4049/jimmunol.1400676

FIGURE 6. Correlation of pre-challenge immune responses with protection against M.tb.

FIGURE 6

(A) CD4 and CD8 T cell cytokine responses (IFN-γ, IL-2 or TNF) against PPD or Ag85A/b peptides in the BAL are compared between survivors (no) and rapid progressors (yes) in AERAS-402- (light/dark blue symbols; 10 wks post-boost) or BCG/Ad35-null- (red symbols; peak response) immunized groups. (B) Comparison of the T cell cytokine expression profiles in survivors and rapid progressors for peak PPD-specific CD4 responses (G2) and Ag85A/b-specific CD8 responses (G3, G4). Significant p values (t-test) are indicated; NS: not significant. (C) Spearman correlation between BAL T cell responses in AERAS-402- or BCG/Ad35-null- immunized animals 3 wks post-boost and lung granuloma severity at necropsy. Granuloma prevalence and size scores were summed for either the right or left lung lobes. Spearman’s rho (ρ) and p values are indicated for significant correlations; linear regression fit is shown for illustration.