(A, B) Plasma cholesterol levels in male and female mice on diets for durations as indicated; (C, F) Immunoblot of apolipoprotein B (ApoB) and apolipoprotein A-I (ApoA-I) in fractionated plasma for mice on 20 weeks diet as indicated; (D, G) HPLC chromatogram of plasma cholesterol after 20 weeks on chow or western diet (WD); (E, H) HPLC chromatogram of plasma triglycerides after 20 weeks on chow or western diet (WD); Data is expressed as mean ± SEM (A, B). *p<0.05, **p<0.01, ***p<0.001 vs matched wild-type.