Table 1.
Chow 20 weeks | WD 20 weeks | Chow 30 weeks | WD 30 weeks | WD 20 weeks | |||||
---|---|---|---|---|---|---|---|---|---|
WT | L-sIDOL | WT | L-sIDOL | WT | L-sIDOL | WT | L-sIDOL | LDLR KO† | |
n | 5 | 6 | 7 | 10 | 5 | 7 | 7 | 8 | 7 |
Body Weight (g) | 28.6±1.4 | 28.1±0.8 | 47.1±0.7 | 45.8±1.8 | 31.6±1.0 | 31.5±1.3 | 48.1±1.2 | 47.2±1.1 | 44.2±1.9 |
Liver Weight (g) | 1.1±0.0 | 1.0±0.1 | 4.3±0.3 | 3.9±0.5 | 1.4±0.1 | 1.3±0.1 | 4.0±0.2 | 3.7±0.2 | 2.7±0.4 |
LW/BW (%) | 3.9±0.1 | 3.6±0.2 | 9.2±0.5 | 8.3±0.7 | 4.4±0.1 | 4.2±0.1 | 8.3±0.4 | 7.8±0.4 | 6.0±0.5 |
TGs (mmol/L) | 0.79±0.04 | 0.46±0.04*** | 0.67±0.04 | 1.00±0.06** | 0.60±0.05 | 0.50±0.03 | 0.29±0.03 | 0.54±0.04*** | 6.35±1.09 |
BW – body weight; LW – liver weight; TGs - triglycerides; L-sIDOL – Albumin driven super IDOL transgenic mice; WT – wild type.
p<0.01,
p<0.001 vs matched wild type.
not included in statistical analysis.