Table 1.
Odds ratios and 95% confidence intervals for association between systemic glucocorticoid use and early-onset BCC in the Yale Study of Skin Health
| Characteristic | Cases/Controls | Multivariate OR1 (95% CI) | P-Trend2 |
|---|---|---|---|
| Use of Glucocorticoids | - | ||
| No | 230/222 | 1.00 | |
| Yes | 132/150 | 0.81 (0.58–1.14) | |
| Duration of Glucocorticoid Use | 0.153 | ||
| No use (0 days) | 230/222 | 1.00 | |
| 1–29 days | 99/105 | 0.81 (0.56–1.18) | |
| ≥ 30 days | 23/37 | 0.70 (0.38–1.30) |
Abbreviations: CI, Confidence Interval; MC1R, melanocortin 1 receptor; OR, odds ratio.
1
Adjusted for age at diagnosis (continuous, years), gender, body site of skin biopsy (head, extremity, trunk), hair color (black/dark brown, light brown, blonde/fair, red), skin color (olive, fair, very fair), MC1R non-synonymous variants (0, 1, ≥2), family history of skin cancer (yes, no), ever indoor tanning (yes, no), and sun exposure in warm months (continuous, hours).
2
Based on an ordinal categorical variable.