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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Mar 15;1843(10):2205–2210. doi: 10.1016/j.bbamcr.2014.03.008

Figure 3. Control over InsP3R-mediated Ca2+ release and its importance.

Figure 3

The consequences of insufficient or excessive Ca2+ transfer from ER to mitochondria illustrate why cells have developed a number of mechanisms, including interaction with Bcl-2, to control InsP3R channel opening and Ca2+ release.