Table 2.
Association between Vitamin D SNPs and UL. Genotypic model.
| Gene | SNPa | Risk allele frequency (%) |
P-value for allele frequency difference |
Cases/controls | Unadjusted model | Adjusted modelb | ||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Nominalb | Permutatedb | OR (95% CI) | OR (95% CI) | |||
| GC | rs7041 | |||||||
| TT | 18.2 | 19.0 | 0.350 | 0.993 | 1,369/1,283 | 1.00 | 1.00 | |
| TC | 596/589 | 0.95 (0.83, 1.09) | 1.01 (0.88, 1.16) | |||||
| CC | 72/75 | 0.90 (0.65, 1.25) | 0.98 (0.70, 1.37) | |||||
| GC | rs2298849 | |||||||
| AA | 37.0 | 36.9 | 0.974 | 0.999 | 887/950 | 1.00 | 1.00 | |
| AG | 1,026/1,131 | 0.97 (0.86, 1.10) | 0.96 (0.85, 1.09) | |||||
| GG | 308/322 | 1.02 (0.86, 1.23) | 1.01 (0.84, 1.21) | |||||
| CYP2R1 | rs10766196 | |||||||
| AA | 15.9 | 16.0 | 0.889 | 0.999 | 1,558/1,685 | 1.00 | 1.00 | |
| AG | 590/642 | 0.99 (0.87, 1.13) | 1.05 (0.92, 1.20) | |||||
| GG | 56/62 | 0.98 (0.68, 1.41) | 1.04 (0.72, 1.51) | |||||
| CYP2R1 | rs10741657 | |||||||
| GG | 28.5 | 26.7 | 0.059 | 0.503 | 1,155/1,259 | 1.00 | 1.00 | |
| GA | 855/977 | 0.95 (0.85, 1.08) | 0.96 (0.85, 1.09) | |||||
| AA | 203/149 | 1.49 (1.19, 1.86) | 1.48 (1.18, 1.85) | |||||
| DHCR7 | rs4944957 | |||||||
| GG | 49.2 | 46.8 | 0.022 | 0.225 | 588/669 | 1.00 | 1.00 | |
| GA | 1,069/1,201 | 1.01 (0.88, 1.16) | 1.01 (0.88, 1.16) | |||||
| AA | 554/518 | 1.22 (1.03, 1.43) | 1.19 (1.01, 1.40) | |||||
| DHCR7 | rs12800438 | |||||||
| AA | 61.4 | 58.3 | 0.002 | 0.028 | 327/402 | 1.00 | 1.00 | |
| GA | 1,053/1,187 | 1.09 (0.92, 1.29) | 1.09 (0.92, 1.29) | |||||
| GG | 829/796 | 1.28 (1.07, 1.53) | 1.23 (1.03, 1.47) | |||||
| VDR | rs739837 | |||||||
| AA | 42.3 | 42.1 | 0.837 | 0.999 | 726/756 | 1.00 | 1.00 | |
| AG | 997/1,135 | 0.92 (0.80, 1.04) | 0.92 (0.81, 1.05) | |||||
| GG | 399/394 | 1.05 (0.89, 1.25) | 1.05 (0.88, 1.25) | |||||
| VDR | rs886441 | |||||||
| AA | 39.5 | 39.3 | 0.825 | 0.999 | 735/713 | 1.00 | 1.00 | |
| AG | 988/935 | 1.02 (0.89, 1.17) | 0.99 (0.86, 1.14) | |||||
| GG | 309/296 | 1.01 (0.84, 1.22) | 0.97 (0.80, 1.18) | |||||
| OCA2 | rs1800404 | |||||||
| CC | 22.3 | 23.2 | 0.332 | 0.991 | 1,300/1,382 | 1.00 | 1.00 | |
| TC | 785/811 | 1.03 (0.91, 1.16) | 1.10 (0.97, 1.25) | |||||
| TT | 94/134 | 0.75 (0.57, 0.98) | 0.88 (0.66, 1.17) | |||||
| SLC24A5 | rs1426654 | |||||||
| GG | 22.2 | 22.6 | 0.668 | 0.999 | 1,344/1,429 | 1.00 | 1.00 | |
| GA | 757/846 | 0.95 (0.84, 1.08) | 1.04 (0.91, 1.18) | |||||
| AA | 114/118 | 1.03 (0.79, 1.34) | 1.31 (0.99, 1.74) | |||||
| ASIP | rs6058017 | |||||||
| AA | 66.2 | 62.9 | 0.001 | 0.013 | 253/309 | 1.00 | 1.00 | |
| GA | 929/1,104 | 1.03 (0.85, 1.24) | 1.01 (0.83, 1.22) | |||||
| GG | 941/908 | 1.27 (1.05, 1.53) | 1.18 (0.97, 1.44) | |||||
| CYP24A1 | rs2762941 | |||||||
| GG | 49.9 | 49.7 | 0.846 | 0.999 | 562/626 | 1.00 | 1.00 | |
| GA | 1,076/1,140 | 1.05 (0.91, 1.21) | 1.03 (0.90, 1.19) | |||||
| AA | 558/612 | 1.02 (0.86, 1.19) | 0.98 (0.83, 1.16) | |||||
a
Order of genotype categories is as follows: top row = homozygous for the reference allele, middle row =heterozygous, bottom row = homozygous for the risk allele.
b
Adjusted for age in 1997, geographic region, and percent European ancestry.
Numbers of cases and controls do not sum to 2,432 and 2,232, respectively, due to missing genotype data.