Table 4.
Association between Vitamin D SNPs and UL by dietary/supplemental intake of vitamin D
| Dietary or supplemental intake of vitamin D | ||||
|---|---|---|---|---|
| <5 mcg/d (<200 IU) and no supplements |
≥5 mcg/d (≥200 IU) or supplements |
|||
| SNP | Cases/ controls |
Adjusted modela OR (95% CI) |
Cases/ controls |
Adjusted modela OR (95% CI) |
| rs12800438 | ||||
| AA/GA | 1,183/1,323 | 1.00 (ref.) | 197/266 | 1.00 (ref.) |
| GG | 715/665 | 1.16 (1.01, 1.33) | 114/131 | 1.15 (0.84, 1.57) |
| rs6058017 | ||||
| AA/GA | 999/1,177 | 1.00 (ref.) | 183/236 | 1.00 (ref.) |
| GG | 820/757 | 1.23 (1.07, 1.41) | 121/151 | 0.99 (0.72, 1.35) |
| Sum of homozygous GG genotypes |
||||
| None | 329/251 | 1.00 (ref.) | 107/154 | 1.00 (ref.) |
| One | 842/873 | 1.31 (1.00, 1.72) | 153/176 | 1.19 (0.85, 1.65) |
| Two | 637/779 | 1.53 (1.24, 1.88) | 39/51 | 1.05 (0.64, 1.71) |
a
Adjusted for age in 1997, geographic region, and percent European ancestry.
Numbers of cases and controls do not sum to 2,432 and 2,232, respectively, due to missing genotype data.