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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Curr Opin Immunol. 2014 Jun 12;0:97–104. doi: 10.1016/j.coi.2014.05.006

Figure 2. Autophagic functions in adaptive immunity.

Figure 2

In dendritic cells, cytosolic proteins or those derived from intracellular pathogens can be delivered to be loaded into MHC-II through macroautophagy, CMA or endosomal microautophagy (e-microautophagy) to activate T cells. Whereas basal macroautophagy in T cells regulates organelle homeostasis (including mitochondria and endoplasmic reticulum), activation-induced macroautophagy in response to TCR engagement degrades cytosolic components to respond to increased metabolic demand and to modulate specific signaling pathways.