Table 1.
Selected gene-related functions of adverse prognostic markers identified in ES tumors, according to the NCBI AceView database (http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/index.html)
| No | Gene symbol | Gene name | Function |
|---|---|---|---|
| 1 | CCND1 | Cyclin D1 | Cyclin-dependent protein kinase regulator activity, protein kinase activity, cell division, regulation of cell cycle |
| 2 | CDH2 | Cadherin 2, type 1, N-cadherin (neuronal) | Cell adhesion, calcium-dependent cell–cell adhesion, cell migration |
| 3 | CDH11 | Cadherin 11, type 2, OB-cadherin (osteoblast) | Cell adhesion, skeletal system development |
| 4 | CDT2 | Denticleless homolog (Drosophila) | Ubiquitin–protein ligase activity (protein mono- and polyubiquitination), regulation of cell cycle (G2/M transition DNA damage checkpoint), DNA replication |
| 5 | MTA1 | Metastasis associated 1 | Transcription factor activity; regulation of transcription, DNA-dependent |
| 6 | STEAP1 | Six transmembrane epithelial antigen of the prostate 1 | Transporter activity, channel activity |