Table 2. Exercise capacity in HFpEF.
| Upper pVO2 tertile 15.9 (14.4, 16.9) | Middle pVO2 tertile 11.7 (11.2, 12.4) | Lower pVO2 tertile 9.4 (8.3, 10.2) | P-value | |
|---|---|---|---|---|
| N | 73 | 71 | 71 | |
| Six minute walk distance, m | 368 (293, 442) | 328 (246, 382) | 236 (160, 306) | <0.001 |
| Exercise modality | 0.017 | |||
| Cycle | 38 (52%) | 53 (75%) | 43 (61%) | |
| Treadmill | 35 (48%) | 18 (25%) | 28 (39%) | |
| Rest hemodynamics | ||||
| Systolic BP, mmHg | 123 (112, 140) | 128 (114, 140) | 120 (110, 132) | 0.37 |
| Diastolic BP, mmHg | 74 (66, 80) | 70 (64, 76) | 68 (60, 76) | 0.04 |
| Heart rate, bpm | 67 (60, 76) | 69 (60, 80) | 70 (60, 76) | 0.89 |
| Peak exercise hemodynamics | ||||
| Systolic BP, mmHg | 162 (146, 190) | 158 (134, 172) | 138 (120, 158) | <0.001 |
| Diastolic BP, mmHg | 80 (61, 90) | 72 (64, 80) | 70 (60, 73) | 0.004 |
| Heart rate, bpm | 119 (111, 134) | 106 (92, 128) | 94 (81, 109) | <0.001 |
| Chronotropic index | 0.60 (0.48, 0.72) | 0.47 (0.32, 0.67) | 0.29 (0.17, 0.52) | <0.001 |
| Chronotropic incompetence | 47 (65%) | 55 (79%) | 62 (87%) | 0.007 |
| Respiratory exchange ratio | 1.1 (1.0, 1.2) | 1.1 (1.0, 1.2) | 1.09 (1.0, 1.2) | 0.82 |
| Borg score | 8 (6, 9) | 7 (5, 9) | 7 (5, 8) | 0.049 |
| Exercise duration, min | 12 (10, 14) | 10 (8, 11) | 7 (6, 9) | <0.001 |
| VO2, ml/min | 1503 (1289, 1784) | 1066 (902, 1278) | 860 (689, 1120) | <0.001 |
| VO2, ml/kg/min | 15.9 (14.4, 16.9) | 11.7 (11.2, 12.4) | 9.4 (8.3, 10.2) | N/A |
| VO2 at AT, ml/min/kg | 9.1 (8.3, 10.3) | 7.0 (6.3, 7.9) | 6.0 (5.4, 6.6) | <0.001 |
| VO2 at AT (% of pVO2) | 59 (53, 64) | 60 (54, 66) | 67 (60, 71) | <0.001 |
| % Predicted pVO2† | 75.48 (68.16, 84.03) | 66.84 (56.65, 77.03) | 54.9 (45.99, 64.84) | <0.001 |
Abbreviations: AT, anaerobic threshold; BP, blood pressure; pVO2, peak oxygen consumption;
†
Wasserman Equation