Table 3.

Optimization of encapsulation of liposomal Res.

Drug : lipid ratio (w/w)	Encapsulation efficiency (%)
1 : 10	20.93 ± 1.83a
1 : 20	18.93 ± 0.6244a
1 : 40	52.36 ± 2.71
1 : 60	53.74 ± 10.17
1 : 40 : 8∗	35.98 ± 5.52
1 : 20 : 1∗	20.21 ± 2.7b
1 : 40 : 1∗	27.14 ± 2.97
1 : 40 : 2∗	33.46 ± 1.91
1 : (38 : 2)∗∗	26.55 ± 4.85
1 : (18 : 2)∗∗	38.91 ± 2.58c
1 : 1 : (18 : 2)∗∗∗	41.56 ± 0.695c

^adenotes that these groups are significantly different from 1 : 40 ratio (P < 0.05).

^bdenotes that the group is significantly different from the 1 : 40 : 2 ratio (P < 0.05).

^cdenotes that the group is significantly different from the 1 : 38 : 2 ratio (P < 0.05).

∗denotes Res : EPC : 5-FU (dual encapsulated formulation without DSPE-PEG).

∗∗denotes Res : EPC : DSPE-PEG (PEGylated Res formulation).

∗∗∗denotes 5-FU :  Res : EPC : DSPE-PEG (PEGylated dual liposomal formulation).