Table 2. Substrate Scope of the Asymmetric Fluorination of 2-Aryl Cyclohexanones^a,b,c.

^aReactions were carried out with ketone (0.2 mmol), Selectfluor (0.1 mmol) amine catalyst (0.02 mmol), phosphoric acid catalyst (0.005 mmol), and Na₂CO₃·H₂O (0.2 mmol) in toluene (1.0 mL) for 40 h at rt.

^bYields are isolated yields after chromatography. Primary yields calculated based on the excess ketone employed. Yields in parentheses calculated based on Selectfluor, the limiting reagent in all cases.

^cAbsolute configurations assigned by analogy to 2j, determined by X-ray crystallography.

^dCharacterized as the N-tosyl derivative.