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(a) Summary of E-dependent ERα signalling (yellow) and the potential independent activities of E (blue) and ERα (red). (b) Comparison of the impact of AIs and SERDs on classical and non-classical oestrogenic signalling, illustrating activities targeted by both agents (yellow) and those affected specifically by AIs (blue) or fulvestrant (red), reduced activity is indicated by downward arrows (solid black) and no change is indicated by horizontal arrows (black outline).
