Table 1.

Ingenuity based biological interpretation of genes specifically affected by fulvestrant in pre-surgical studies and in vitro models: (a) Network functions and (b) Canonical pathways.

(a)
Canonical Pathways	p-value	Genes
G Beta Gamma Signaling	9.120E-03	CAV1,CAV2
Estrogen-mediated S-phase Entry	3.890E-02	SKP2
Antiproliferative Role of TOB in T Cell Signaling	4.169E-02	SKP2
Cell Cycle: G2/M DNA Damage Checkpoint Regulation	6.761E-02	SKP2
Semaphorin Signaling in Neurons	8.128E-02	NRP1

(b)
Molecules in Network	Score	Focus Molecules	Top Functions
Akt, Alphatubulin, AR, CAV1, CAV2, CD55, CHTF18, CXCL12, E2f, EMC9, EP300, ERK, estrogen receptor, EWSR1, FANCA, FNTA, GTSE1, HBEGF, HIF1A, LRP8, NRP1 (includes EG:18186), P38 MAPK, POLH, PPME1, RBM14, RFC3, SEPP1, SKA2, SKP2 (includes EG:27401), SMARCA4, SNAI2, STRA13, TFF3, TJP2, TP53 (includes	40	17	Cell Cycle, Cell Death and Survival, Tumor Morphology
RBMS1, SUZ12	2	1	Embryonic Development, Cancer, Skeletal and Muscular Disorders
CD63, SYTL4	2	1	Cell Morphology, Endocrine System Development and Function, Nervous System Development and Function
FBL, NOP56	2	1	RNA Post-Transcriptional Modification, Hereditary Disorder, Neurological Disease
AGTR1, NSUN2, PMS2	2	1	Cancer, Gastrointestinal Disease, Hereditary Disorder