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Pharmacodynamics of SAHA in 5 cats administered 250 mg/m2 oral SAHA with food. PBMC collected at 0 (pre-dose), 1, and 2 hours after SAHA administration were analyzed by Western blotting for both acetylated and total histone H3. Densitometry ratios of acetylH3/totalH3 were normalized to pre-dose controls (time 0). Values above the dashed black line (1) have a relative increase in histone H3 acetylation.
