Table 1.
In Vitro Antimalarial Activities of Ligands and Complexes Against D6 and W2 strains of Plasmodium falciparum.
| Compound | D6 IC50 (µM) |
D6 SI | W2 IC50 (µM) | W2 SI | VERO IC50 ng/mL |
|---|---|---|---|---|---|
| L1 | 2.679 | >4.4 | 4.358 | >2.7 | NC |
| Mn(L1)Cl2 | 0.157 | 38.45 | 0.127 | 47.793 | 3222.8 |
| Fe(L1)Cl2 | 0.324 | >27.6 | 0.426 | >21 | NC |
| [Co(L1)(OAc)]PF6 | NA | - | 5.162 | >1.4 | NC |
| [Ni(L1)(OAc)]PF6 | 0.825 | >8.6 | 1.326 | >5.4 | NC |
| [Cu(L1)(OAc)]PF6 | 0.423 | >16.7 | 0.809 | >8.7 | NC |
| [Zn(L1)(OAc)]PF6 | 0.342 | >20.6 | 0.593 | >11.9 | NC |
| L2 | 1.350 | >9.3 | 2.008 | >6.3 | NC |
| Mn(L2)Cl2 | 0.265 | >35.6 | 0.545 | >17.3 | NC |
| Fe(L2)Cl2 | 1.384 | >6.8 | 2.139 | >4.4 | NC |
| [Co(L2)(OAc)]PF6 | NA | - | NA | - | NC |
| [Ni(L2)(OAc)]PF6 | 1.110 | >6.7 | 1.538 | >4.8 | NC |
| [Cu(L2)(OAc)]PF6 | 0.147 | >50.3 | 0.312 | >23.6 | NC |
| [Zn(L2)(OAc)]PF6 | 2.057 | >3.6 | 3.814 | >1.9 | NC |
| L3 | 1.278 | >6.4 | 1.414 | >5.8 | NC |
| [Mn2(L3)Cl4] | 0.957 | >6 | 0.959 | >5.9 | NC |
| Fe(L3)2Cl4 | NA | - | NA | - | NC |
| [Co2(L3)(OAc)2](PF6)2 | NA | - | NA | - | NC |
| Ni2(L3)(OAc)2](PF6)2 | NA | - | NA | - | NC |
| [Cu2(L3)(OAc)2](PF6)2 | NA | - | NA | - | NC |
| [Zn2(L3)(OAc)2](PF6)2 | NA | - | NA | - | NC |
| Artemisinin (ART) | 0.024 | >>35.5 | 0.004 | >211.4 | NC |
| Chloroquine (CQ) | 0.037 | 20.4 | 0.679 | >1.1 | NC |
NC, no cytotoxicity up to about 10 µM; NA, no activity; SI, selectivity index (IC50 for Vero cells/IC50 for P. falciparum)