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. Author manuscript; available in PMC: 2014 Aug 3.
Published in final edited form as: J Immunol. 2011 Jan 19;186(4):2056–2064. doi: 10.4049/jimmunol.1003013

Figure 2. Vβ gene usage is altered in the gB-8p specific CD8+ T cell responses elicited in mice of different ages.

Figure 2

Dominant Vβ10 (A) and subdominant Vβ8 (B) usage in gB-8p specific CD8+ T cell responses were compared between mice of different ages at the respective peaks of the response (as described in Figure 1). Significant differences in the percentages of Vβ10 and Vβ8 gB-8p-specific CD8+ T cells were found across age groups (p=0.0028 and p=0.0031, respectively; Kruskal-Wallis). In particular, the percentage of Vβ8 gene usage by gB-8p-specific CD8+ T cells was significantly different between 2-3 mo mice and both 18 mo and 22 mo mice (B). A Mann-Whitney test was used for each pairwise comparison, with the statistical significance for each pairwise comparison determined at p<0.0083 (*), using Bonferroni correction for multiple pairwise comparisons. Results are representative of at least 2 separate experiments.