. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Hum Immunol. 2014 May 4;75(8):715–729. doi: 10.1016/j.humimm.2014.04.016

Table 3.

HLA allele association with low/moderate or moderate/high prevalence of HSV-2 infection organized by region: HLA-A*24, HLA-B*27, HLA-B*44, HLA-B*53, HLA-B*58.

Region associated with HIGH allele frequency	Association of high frequency of HLA alleles with moderate/high HSV-2 prevalence	Association of high frequency of HLA alleles with low/moderate HSV-2 prevalence	HSV-2 Infection Prevalence
Asia	HLA-A*24	HLA-B*44	Variable by sub-region
Asia	HLA-B*27	HLA-B*44	Variable by sub-region

Europe	HLA-B*27	HLA-B*44	Low/Moderate

Middle East	-	HLA-B*44	Low

North Africa	-	HLA-B*44	Low

South/Central America	HLA-A24, HLA-B53	-	High

Sub-Saharan Africa	HLA-A24, HLA-B27, HLA-B*58	-	High