Table 4.
Summary of all HLA class I allele associations with prevalence of HSV-2 infection.
| HLA allele | Association with HSV-2 infections and diseases | Regions associated with HIGH allele frequency |
|---|---|---|
| HLA-A*01 | Unclear | Australia, Europe, Middle East, North Africa, sub-Saharan Africa |
| HLA-A*02 | Unclear | Australia, Europe, North Africa, South/Central America, sub-Saharan Africa |
| HLA-A*24 | Positive 1 | Asia, sub-Saharan Africa, South/Central America |
| HLA-B*07 | Unclear | Europe, sub-Saharan Africa |
| HLA-B*08 | Unclear | Sub-Saharan Africa |
| HLA-B*15 | Unclear | Asia, North America, South/Central America, sub-Saharan Africa |
| HLA- B*27 | Positive 1 | Asia, Europe, sub-Saharan Africa |
| HLA-B*35 | Unclear | Asia, Europe, Middle East, North Africa, South/Central America |
| HLA-B*44 | Negative 2 | Asia, Europe, Middle East, North Africa |
| HLA-B*53 | Positive 1 | South/Central America |
| HLA-B*58 | Positive 1 | Sub-Saharan Africa |
| HLA-C*02 | Unclear | Europe, sub-Saharan Africa |
| HLA-C*07 | Unclear | Europe, Middle East, North Africa, North America, South/Central America |
1
HLA allele association with HIGH prevalence of HSV-2 infection, i.e. “susceptibility”
2
HLA allele association with LOW prevalence of HSV-2 infection, i.e. “resistance”