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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2014 Jun 11;134(2):325–331.e9. doi: 10.1016/j.jaci.2014.04.028

Figure 2.

Figure 2

Fungus-specific IL-4 and IgE responses predict Th2-associated disease. Subjects with and without Th2-associated disease (Th2 and no Th2, respectively) were assessed for (A) specific serum IgE and (B) IL-4 memory recall responses from PBMC against whole cell antigens derived from the fungi A. alternata, A. fumigatus, and A. niger, both individually and combined. For the combined analysis, the largest positive response obtained with any of the three fungal antigens was plotted. Values above dotted lines represent positive responses. (C) Relative Operating Characteristic (ROC) curve analyses for both IgE and IL-4 reactivity using optimal IgE & IL-4 cutoff values of 6 kIU/L and 50 cells/106 PBMCs, respectively. AUC: area under the curve.* p<0.05, ** p<0.01, *** p<0.001.