Skip to main content
. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: J Inherit Metab Dis. 2014 Feb 3;37(5):735–743. doi: 10.1007/s10545-013-9675-2

Figure 4. Effect of NTBC treatment upon phenylalanine and tyrosine concentrations in blood and brain of Pahenu2/enu2 mice.

Figure 4

Serum tyrosine concentration in Pahenu2/enu2 mice (Pah−/−) is significantly lower than in wild type (Pah+/+) mice (c) while serum (a) and brain (b) phenylalanine are significantly elevated as expected. There was a trend toward lower brain tyrosine in Pahenu2/enu2 mice in comparison to controls (d) but this difference did not reach statistical significance. NTBC treatment of Pahenu2/enu2 mice led to significantly increased serum (c) and brain tyrosine (d) while decreasing both serum (a) and brain (b) phenylalanine. Data are presented as mean ± SEM. Statistical analysis utilized one-way ANOVA with intergroup p values calculated using Bonferonni’s Multiple Comparison Test.