Table 1.

Effect of NTBC treatment upon serum and brain amino acids in Pah^enu2/enu2 mice.

	Serum (µM)				Brain (nmol/g)
Amino acid	Pah −/−	Pah−/− +NTBC	Mean % change	p value	Pah− /−	Pah−/− +NTBC	Mean % change	p value
Phenylalanine	2474 ± 99	1933 ± 109	−21.9	0.0009	693 ± 49	391 ± 20	−43.6	< 0.0001
Tyrosine	43 ± 3	256 ± 13	+595	< 0.0001	81 ± 15	110 ± 5	+35.8	0.0385
Tryptophan	63 ± 3	48 ± 4	−23.8	0.0045	20 ± 1	12 ± 1	−40.0	0.0004
Valine	252 ± 10	242 ± 11	−4.0	0.515 8	164 ± 9	111 ± 5	−32.3	0.0002
Leucine	176 ± 8	159 ± 11	−9.7	0.215 8	284 ± 16	193 ± 10	−32.0	0.0002
Isoleucine	116 ± 5	109 ± 9	−6.0	0.528 7	105 ± 6	80 ± 3	−23.8	0.0028
Methionine	61 ± 5	99 ± 18	+62.3	0.078 3	62 ± 4	51 ± 3	−17.7	0.0452
Histidine	69 ± 3	69 ± 3	0	0.922 9	114 ± 6	75 ± 4	−34.2	< 0.0001
Threonine	150 ± 9	171 ± 13	+14.0	0.096 6	261 ± 14	201 ± 8	−23.0	0.0022
Lysine	259 ± 32	252 ± 20	−2.7	0.419 9	312 ± 17	265 ± 12	−15.1	0.0210
Aspartic acid¶	13 ± 2	13 ± 12	0	0.4717	2073 ± 126	1895 ± 113	−8.6	0.1552

Serum and brain amino acid concentrations expressed as mean ± SE. p values calculated using one-tailed Students’ t test.

Data for which the difference between the means of NTBC-treated and untreated Pah^enu2/enu2 mice was significant (p < 0.05) are displayed in blue .

^¶Aspartic acid is displayed here as a reference amino acid that is not appreciably transported by the LAT-1 transporter.