Table 1.
Summary of previous significant results published for SNPs assessed for endometrial cancer risk
| SNP | Gene | Ref | Genotype | No. of cases (%) | No. of controls (%) | Adj OR (95%CI) |
|---|---|---|---|---|---|---|
| rs1801030 SULT1A1* 3, 667A>G, Met233Val | SULT1A1 | (Rebbeck 2006) | 421 | 1023 | ||
| AA | 392 (93.1) | 863 (84.4) | 1 (ref) | |||
| GG/AG | 29 (6.9) | 160 (15.6) | 0.51 (0.29-0.92) a | |||
| rs3736599-64G>A | SULT1E1 | (Rebbeck 2006) | 496 | 1306 | ||
| GG | 393 (79.2) | 1061 (81.2) | 1 (ref) | |||
| AA/AG | 103 (20.8) | 245 (18.8) | 1.45 (1.06-1.99) a | |||
| rs2308321 520A>G, Ile143Val | MGMT | (Han 2006) | 445 | 1089 | ||
| AA | 340 (76.4) | 838 (77.0) | 1 (ref) | |||
| AG | 99 (22.3) | 234 (21.5) | ||||
| GG | 6 (1.4) | 17 (1.6) | ||||
| AG/GG | 105 (23.6) | 251 (23.0) | 1.05 (0.8-1.39) b | |||
| AA & never smoked | 1 (ref) | |||||
| AG/GG & >30 pack-years smoking | 0.41 (0.19-0.86) b,c | |||||
| rs12917 343C>T, Leu84Phe | MGMT | (Han 2006) | 434 | 1085 | ||
| CC | 344 (79.3) | 822 (75.8) | 1 (ref) | |||
| CT | 82 (18.9) | 242 (22.3) | ||||
| TT | 8 (1.8) | 21 (1.9) | ||||
| CT/TT | 90 (20.7) | 263 (24.2) | 0.72 (0.53-0.96) c | |||
| rs8135424 Intron 14, G>A | CHEK2 | (Einarsdottir 2007) | 683 | 1524 | ||
| GG | 490 (71.7) | 1156 (75.9) | 1 (ref) | |||
| GA | 170 (24.9) | 343 (22.5) | 1.18 (0.95-1.46) d | |||
| AA | 23 (3.4) | 25 (1.6) | 2.11 (1.18-3.77) d | |||
| per allele | 1.26 (1.06-1.51) d | |||||
Adjusted for: Education (<high school [HS], HS graduate, HS but <college graduate, or >college graduate); BMI from 40 yrs through 49 yrs (continuous); number of full-term pregnancies (never pregnant or 1-2 or ≥3); years of menses, imputed if missing (continuous); type of menopause (known natural, assumed natural at reference age of 50 yrs if menopausal status is unknown, or induced); interaction of never, former, or current smoker by years of smoking; oral contraceptive use (never, <3 yrs, or ≥3 yrs)
Adjusted for: age at menarche (<12, 12, 13, >13 yrs), age at menopause (<48, ≥48 to <50, ≥50 to <53 or ≥53 yrs), BMI at age 18 yrs (continuous), weight gain since age 18 (<5, ≥5 to <20, ≥20 kg), postmenopausal hormone use at diagnosis (current, not current), parity/age at first birth (nulliparous, with children/age at first birth ≤24 yrs, with children/age at first birth >24 yrs), pack-years of smoking (never, >0 to <30, ≥30), first-degree family history of endometrial cancer (yes/no), first-degree history of colorectal cancer (yes/no)
p-trend = 0.01, p for interaction with smoking = 0.04
Adjusted for: Age (5 year groups)