Table 2.
Estimated odds ratios (OR) and 95% confidence intervals (CI) in the Australian and Polish Sample Sets
| SNP | Gene | Genotype | pooled Adj OR (95%CI) a | P-value | No. of cases (%) | No. of controls (%) | No. of cases (%) | No. of controls (%) |
|---|---|---|---|---|---|---|---|---|
| ANECS | PECS | |||||||
| rs1801030 | SULT1A1 | 1165 | 1094 | 392 | 404 | |||
| AA | Not polymorphic | 1165 (100) | 1094 (100) | 392 (100) | 404 (100) | |||
| RS3736599 | SULT1E1 | 1110 | 1050 | 397 | 407 | |||
| CC | 1 (ref) | 906 (81.6) | 869 (82.8) | 328 (82.6) | 342 (84.1) | |||
| CT | 1.10 (0.89-1.35) | 0.39 | 193 (17.4) | 171 (16.3) | 66 (16.6) | 60 (14.7) | ||
| TT | 0.83 (0.39-1.75) | 0.62 | 11 (1.0) | 10 (1.0) | 3 (0.8) | 5 (1.2) | ||
| per allele | 1.05 (0.87-1.27) | 0.60 | ||||||
| rs2308321 | MGMT | 1170 | 1091 | 396 | 404 | |||
| AA | 1 (ref) | 924 (79.0) | 861 (78.9) | 305 (77.0) | 317 (78.5) | |||
| AG | 1.00 (0.83-1.20) | 0.99 | 231 (19.7) | 220 (20.2) | 83 (21.0) | 80 (19.8) | ||
| GG | 1.28 (0.67-2.43) | 0.45 | 15 (1.3) | 10 (0.9) | 8 (2.0) | 7 (1.7) | ||
| per allele | 1.03 (0.87-1.21) | 0.74 | ||||||
| RS12917 | MGMT | 1173 | 1099 | 397 | 406 | |||
| CC | 1 (ref) | 889 (75.8) | 810 (73.7) | 278 (70.0) | 296 (72.9) | |||
| CT | 0.94 (0.80-1.12) | 0.49 | 261 (22.3) | 270 (24.6) | 108 (27.2) | 103 (25.4) | ||
| TT | 1.22 (0.72-2.10) | 0.45 | 23 (2.0) | 19 (1.7) | 11 (2.8) | 7 (1.7) | ||
| per allele | 0.99 (0.85-1.14) | 0.84 | ||||||
| rs8135424 | CHEK2 | 1200 | 1090 | 382 | 378 | |||
| GG | 1 (ref) | 1015 (84.6) | 887 (81.4) | 277 (72.5) | 260 (68.8) | |||
| AG | 0.83 (0.69-1.01) | 0.06 | 179 (14.9) | 194 (17.8) | 99 (25.9) | 111 (29.4) | ||
| AA | 0.66 (0.31-1.41) | 0.28 | 6 (0.5) | 9 (0.8) | 6 (1.6) | 7 (1.8) | ||
| per allele | 0.83 (0.70-0.99) | 0.03 | ||||||
a
Adjusted for age (continuous) and study (ANECS, PECS)
Abbreviations: ANECS - Australian National Endometrial Cancer Study; PECS - Polish Endometrial
Cancer Study