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. 2014 Jul 8;111(3):486–496. doi: 10.1038/bjc.2014.152

Figure 7.

Figure 7

Schematic illustration for the role of PD2 in CSCs. The isolated cancer stem cells by flow sort method were analysed for the tumorigenicity and tumourspheres formation. Isolated CSC populations overexpress PD2 and maintain the self-renewal and drug resistance property. The knockdown of PD2 in CSCs along with drug treatment reduces the viability of CSCs. Furthermore, PD2 inhibition changed the CSC phenotype and downregulated CSC and drug resistance markers. Overall, the diagram demonstrates the role of PD2 in the maintenance of CSCs and drug resistance.