Table 2. Univariate and multivariate analysis of factors associated with overall survival.
|
Univariate analysis |
Multivariate analysis |
|||||
|---|---|---|---|---|---|---|
| MS | 3-year OS | P | HR | CI | P | |
|
Age >70 years | ||||||
| N | 71 | 78 | 0.88 | |||
| Y |
76 |
66 |
|
|
|
|
|
Sex | ||||||
| Female | 81 | 70 | 0.85 | |||
| Male |
67 |
79 |
|
|
|
|
|
Primary tumour | ||||||
|
Stage T | ||||||
| T1T2 | NR | 79 | 0.19 | |||
| T3T4 |
71 |
80 |
|
|
|
|
|
N positive | ||||||
| N | NR | 90 | 0.03 | 2.17 | 1.21–4.08 | 0.01 |
| Y |
68 |
75 |
|
|
|
|
|
Rectum location | ||||||
| N | 73 | 77 | 0.31 | |||
| Y |
71 |
73 |
|
|
|
|
|
CLM | ||||||
|
Max size >5 cm | ||||||
| N | 72 | 78 | 0.03 | |||
| Y |
45 |
60 |
|
|
|
|
|
No. CLM>3 | ||||||
| N | 78 | 78 | 0.02 | |||
| Y |
54 |
76 |
|
|
|
|
|
Bilobar location | ||||||
| N | 76 | 77 | 0.11 | |||
| Y |
65 |
75 |
|
|
|
|
|
Initially resectable | ||||||
| N | 86 | 78 | 0.09 | |||
| Y |
65 |
75 |
|
|
|
|
|
CEA >200 ng ml−1 | ||||||
| N | 67 | 77 | 0.08 | |||
| Y |
42 |
63 |
|
|
|
|
|
Preoperative portal vein embolization | ||||||
| N | 76 | 79 | 0.001 | 2.01 | 1.13–3.51 | 0.01 |
| Y |
44 |
65 |
|
|
|
|
|
Synchronous | ||||||
| N | 73 | 79 | 0.80 | |||
| Y |
67 |
69 |
|
|
|
|
|
Positive margins | ||||||
| N | 72 | 77 | 0.55 | |||
| Y |
67 |
75 |
|
|
|
|
|
Pathologic response | ||||||
|
Necrosis⩾50% | ||||||
| N | 67 | 0.03 | ||||
| Y |
NR |
|
|
|
|
|
|
Method of Blazer et al | ||||||
| 0 | NR | 100 | 0.127 | |||
| 1–49% | 72 | 74 | ||||
| ⩾ 50% |
68 |
76 |
|
|
|
|
|
Method of Rubbia-Brandt et al | ||||||
| TRG1–2 | NR | 93 | 0.06 | |||
| TRG3 | 73 | 76 | ||||
| TRG4–5 |
68 |
74 |
|
|
|
|
|
New proposed method* | ||||||
| 0 | NR | 100 | 0.0003 | 3.29 | 1.59–6.80 | 0.001 |
| 0.1–6 | 71 | 76 | ||||
| >6 | 48 | 63 | ||||
Abbreviations: CEA=carcinoembryonic antigen; CI=confidence interval; CLM=colorectal liver metastases; HR=hazard ratio; MS=median survival; N=no; NR=not reached (for median survival); OS=overall survival; Y=yes.
*
