Table 2. Cox proportional hazard models for recurrence-free survival.

	Unadjusted		Adjusted
Parameter	HR (95% CI)	P-value	HR (95% CI)	P-value
NLR (⩾3 vs <3)	1.53 (1.23–1.89)	<0.001	1.49 (1.12–2.00)	0.007
Age	1.01 (1.00–1.02)	0.22	1.00 (0.98–1.03)	0.93
Gender (female vs male)	0.96 (0.68–1.34)	0.79	0.87 (0.60–1.27)	0.48
Charlson comorbidity index	1.08 (0.99–1.18)	0.078	1.04 (0.98–1.11)	0.17
Haemoglobin (per 10 units)	0.89 (0.86–0.93)	<0.001	0.97 (0.95–1.00)	0.014
Platelets (per 100 units)	1.24 (1.10–1.38)	<0.001	1.17 (1.10–1.25)	<0.001
T-stage (pT3–4 vs pT0–2)	2.75 (1.99–3.80)	<0.001	1.51 (0.97–2.34)	0.067
N-Stage (N+ vs N0/Nx)	3.01 (2.68–3.38)	<0.001	2.16 (1.82–2.57)	<0.001
Positive surgical margin	2.07 (1.33–3.22)	0.001	1.99 (1.28–3.10)	0.002
Year of radical cystectomy	1.00 (0.97–1.03)	0.93	1.00 (0.97–1.03)	>0.99
Lymphovascular invasion	2.91 (1.88–4.52)	<0.001	1.82 (1.13–2.95)	0.014
NAC/primary chemotherapy	0.93 (0.43–2.01)	0.86	0.90 (0.41–1.97)	0.79
Adjuvant chemotherapy	1.56 (1.21–2.00)	<0.001	0.89 (0.55–1.42)	0.61

Abbreviations: CI=confidence interval; HR=hazard ratio; NAC=neo-adjuvant chemotherapy; NLR=neutrophil-to-lymphocyte ratio.