Table 3. Cox proportional hazard models for cancer-specific survival.

	Unadjusted		Adjusted
Parameter	HR (95% CI)	P-value	HR (95% CI)	P-value
NLR (⩾3 vs <3)	1.88 (1.52–2.33)	<0.001	1.88 (1.39–2.54)	<0.001
Age	1.01 (0.99–1.04)	0.19	1.00 (0.97–1.04)	0.88
Gender (female vs male)	1.17 (0.95–1.46)	0.14	1.10 (0.87–1.40)	0.41
Charlson Comorbidity Index	1.16 (1.06–1.28)	0.002	1.16 (1.09–1.24)	<0.001
Haemoglobin (per 10 units)	0.87 (0.82–0.91)	<0.001	0.96 (0.92–0.99)	0.013
Platelets (per 100 units)	1.28 (1.14–1.44)	<0.001	1.19 (1.03–1.37)	0.019
T-stage (pT3–4 vs pT0–2)	3.12 (2.18–4.47)	<0.001	1.65 (1.06–2.56)	0.026
N-stage (N+ vs N0/Nx)	3.21 (2.14–4.81)	<0.001	2.26 (1.38–3.70)	0.001
Positive surgical margin	1.98 (1.03–3.82)	0.041	1.61 (0.79–3.31)	0.19
Year of radical cystectomy	0.98 (0.92–1.04)	0.50	0.96 (0.90–1.03)	0.30
Lymphovascular invasion	3.09 (1.98–4.82)	<0.001	1.91 (1.10–3.34)	0.023
NAC/primary chemotherapy	1.47 (0.66–3.25)	0.34	1.33 (0.59–2.98)	0.50
Adjuvant chemotherapy	1.36 (1.01–1.83)	0.041	0.95 (0.49–1.86)	0.89

Abbreviations: CI=confidence interval; HR=hazard ratio; NAC=neo-adjuvant chemotherapy; NLR=neutrophil-to-lymphocyte ratio.