Table 3. Likelihood of receipt of lung cancer chemotherapy, by SEP, adjusted for selected patient, tumour and system factors, for full cohort.
| |
Receiving chemotherapy (8348/28 733) |
Unadjusted (n=28 733) |
Adjusted – sex, age, year, comorbidity score, GP referral, stage, PS, histological subtype (n=28 733,
R2=34.97%) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | N | % | OR | (95% CI) | P | OR | (95% CI) | P | ||
| Deprivation quintile |
8348 |
29.1 |
|
|
|
<0.001 |
|
|
|
<0.001 |
| 1 (least deprived) | 1133 | 33.4 | 1.00 | 1.00 | ||||||
| 2 | 1275 | 30.5 | 0.87 | 0.79 | 0.96 | 0.85 | 0.75 | 0.96 | ||
| 3 | 1425 | 29.4 | 0.83 | 0.75 | 0.91 | 0.82 | 0.73 | 0.93 | ||
| 4 | 1898 | 28.3 | 0.79 | 0.72 | 0.86 | 0.70 | 0.63 | 0.79 | ||
| 5 (Most deprived) |
2617 |
27.2 |
0.75 |
0.69 |
0.81 |
|
0.64 |
0.58 |
0.72 |
|
| Sex |
8348 |
29.1 |
|
|
|
|
|
|
|
0.43 |
| Female | 3810 | 28.8 | 1.00 | |||||||
| Male |
4538 |
29.3 |
|
|
|
|
1.03 |
0.96 |
1.10 |
|
| Age group |
8348 |
29.1 |
|
|
|
|
|
|
|
<0.001 |
| <60 | 2221 | 60.3 | 1.00 | |||||||
| 60–69 | 3332 | 43.9 | 0.54 | 0.49 | 0.60 | |||||
| 70–79 | 2452 | 23.9 | 0.24 | 0.22 | 0.27 | |||||
| 80+ |
343 |
4.8 |
|
|
|
|
0.05 |
0.05 |
0.06 |
|
| Year of diagnosis |
8348 |
29.1 |
|
|
|
|
|
|
|
<0.001 |
| 2006 | 1506 | 27.2 | 1.00 | |||||||
| 2007 | 1667 | 29.2 | 1.19 | 1.07 | 1.31 | |||||
| 2008 | 1681 | 28.7 | 1.09 | 0.98 | 1.20 | |||||
| 2009 | 1773 | 30.2 | 1.47 | 1.28 | 1.68 | |||||
| 2010 |
1721 |
29.9 |
|
|
|
|
1.49 |
1.29 |
1.72 |
|
| Comorbidity score |
8348 |
29.1 |
|
|
|
|
|
|
|
<0.001 |
| 0 | 1224 | 30.5 | 1.00 | |||||||
| 1–2 | 669 | 19.0 | 0.67 | 0.59 | 0.77 | |||||
| 3+ | 122 | 13.1 | 0.50 | 0.39 | 0.63 | |||||
| Missing | 3503 | 34.4 | 1.12 | 1.00 | 1.24 | |||||
| Unavailable |
2830 |
28.1 |
|
|
|
|
0.76 |
0.67 |
0.85 |
|
| GP referral |
8348 |
29.1 |
|
|
|
|
|
|
|
<0.001 |
| No | 2566 | 19.3 | 1.00 | |||||||
| Yes |
5782 |
37.4 |
|
|
|
|
2.04 |
1.91 |
2.19 |
|
| Stage |
8348 |
29.1 |
|
|
|
|
|
|
|
<0.001 |
| I | 223 | 18.8 | 1.00 | |||||||
| II | 163 | 29.5 | 2.17 | 1.65 | 2.85 | |||||
| III | 1032 | 45.4 | 5.77 | 4.71 | 7.06 | |||||
| IV | 1314 | 35.0 | 4.49 | 3.69 | 5.46 | |||||
| Missing |
5616 |
26.8 |
|
|
|
|
3.55 |
2.90 |
4.34 |
|
| Performance status |
8348 |
29.1 |
|
|
|
|
|
|
|
<0.001 |
| 0 | 1151 | 62.5 | 1.00 | |||||||
| 1–2 | 2067 | 42.5 | 0.49 | 0.43 | 0.56 | |||||
| 3–4 | 113 | 5.2 | 0.04 | 0.03 | 0.05 | |||||
| Missing |
5017 |
25.3 |
|
|
|
|
0.32 |
0.27 |
0.37 |
|
| Histological subtype |
8348 |
29.1 |
|
|
|
|
|
|
|
<0.001 |
| Adenocarcinoma | 1658 | 37.2 | 1.00 | |||||||
| Squamous cell | 1767 | 33.8 | 0.89 | 0.81 | 0.98 | |||||
| Large cell | 271 | 35.3 | 0.94 | 0.79 | 1.12 | |||||
| Non-small cell | 1670 | 35.8 | 0.97 | 0.88 | 1.07 | |||||
| Other (specified) | 377 | 32.6 | 0.84 | 0.72 | 0.98 | |||||
| Small cell | 2381 | 68.1 | 5.25 | 4.70 | 5.86 | |||||
| Unspecified carcinoma | 66 | 12.7 | 0.36 | 0.27 | 0.49 | |||||
| Neoplasm | 158 | 1.9 | 0.08 | 0.06 | 0.09 | |||||
Abbreviations: CCI score=Charlson comorbidity score; CI=confidence interval; IMD=Index of Multiple Deprivation; NSCLC=non-small cell lung cancer; OR=odds ratio; PS=performance status; SCLC=small cell lung cancer; SEP=socioeconomic position.