Table 4. Likelihood of receipt of lung cancer chemotherapy, by SEP, adjusted for selected patient, tumour and system factors, for staged subgroup.
| |
Receiving chemotherapy (2732/7769) |
Unadjusted (n=7769) |
Adjusted – sex, age, year, CCI, GP referral, stage, PS, histological subtype (n=7769,
R2=35.86%) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | N | % | OR | (95% CI) | P | OR | (95% CI) | P | ||
| Deprivation quintile |
2732 |
35.2 |
|
|
|
0.19 |
|
|
|
0.34 |
| 1 (Least deprived) | 351 | 37.7 | 1.00 | 1.00 | ||||||
| 2 | 414 | 37.0 | 0.97 | 0.81 | 1.16 | 1.00 | 0.80 | 1.26 | ||
| 3 | 445 | 34.2 | 0.86 | 0.72 | 1.02 | 1.04 | 0.83 | 1.31 | ||
| 4 | 638 | 34.8 | 0.88 | 0.75 | 1.04 | 0.92 | 0.74 | 1.14 | ||
| 5 (Most deprived) |
884 |
34.1 |
0.86 |
0.73 |
1.00 |
|
0.88 |
0.72 |
1.08 |
|
| Sex |
2732 |
35.2 |
|
|
|
|
|
|
|
0.78 |
| Female | 1255 | 35.3 | 1.00 | |||||||
| Male |
1477 |
35.1 |
|
|
|
|
1.02 |
0.90 |
1.15 |
|
| Age group |
2732 |
35.2 |
|
|
|
|
|
|
|
<0.001 |
| <60 | 690 | 66.3 | 1.00 | |||||||
| 60–69 | 1103 | 50.4 | 0.57 | 0.48 | 0.69 | |||||
| 70–79 | 821 | 28.9 | 0.27 | 0.22 | 0.32 | |||||
| 80+ |
118 |
7.0 |
|
|
|
|
0.06 |
0.05 |
0.08 |
|
| Year of diagnosis |
2732 |
35.2 |
|
|
|
|
|
|
|
0.03 |
| 2006 | 211 | 31.5 | 1.00 | |||||||
| 2007 | 323 | 37.3 | 1.48 | 1.13 | 1.93 | |||||
| 2008 | 556 | 35.7 | 1.39 | 1.09 | 1.77 | |||||
| 2009 | 758 | 35.4 | 1.46 | 1.09 | 1.95 | |||||
| 2010 |
884 |
34.9 |
|
|
|
|
1.46 |
1.08 |
1.97 |
|
| CCI score |
2732 |
35.2 |
|
|
|
|
|
|
|
0.03 |
| 0 | 353 | 35.5 | 1.00 | |||||||
| 1–2 | 203 | 23.7 | 0.74 | 0.57 | 0.95 | |||||
| 3+ | 40 | 17.7 | 0.68 | 0.43 | 1.07 | |||||
| Missing | 800 | 40.5 | 1.05 | 0.84 | 1.33 | |||||
| Unavailable |
1336 |
36.0 |
|
|
|
|
0.92 |
0.74 |
1.15 |
|
| GP referral |
2732 |
35.2 |
|
|
|
|
|
|
|
<0.001 |
| No | 603 | 24.9 | 1.00 | |||||||
| Yes |
2129 |
39.8 |
|
|
|
|
1.98 |
1.72 |
2.28 |
|
| Stage |
2732 |
35.2 |
|
|
|
|
|
|
|
<0.001 |
| I | 223 | 18.8 | 1.00 | |||||||
| II | 163 | 29.5 | 2.26 | 1.71 | 2.98 | |||||
| III | 1032 | 45.4 | 6.06 | 4.92 | 7.46 | |||||
| IV |
1314 |
35.0 |
|
|
|
|
4.70 |
3.84 |
5.75 |
|
| Performance status |
2732 |
35.2 |
|
|
|
|
|
|
|
<0.001 |
| 0 | 933 | 62.5 | 1.00 | |||||||
| 1–2 | 1561 | 40.3 | 0.41 | 0.35 | 0.48 | |||||
| 3–4 | 78 | 4.4 | 0.03 | 0.02 | 0.04 | |||||
| Missing |
160 |
24.9 |
|
|
|
|
0.27 |
0.21 |
0.34 |
|
| Histological subtype |
2732 |
35.2 |
|
|
|
|
|
|
|
<0.001 |
| Adenocarcinoma | 652 | 44.3 | 1.00 | |||||||
| Squamous cell | 732 | 39.6 | 0.81 | 0.68 | 0.96 | |||||
| Large cell | 73 | 43.2 | 0.96 | 0.65 | 1.41 | |||||
| Non-small cell | 683 | 42.1 | 0.91 | 0.77 | 1.09 | |||||
| Other (specified) | 110 | 36.9 | 0.85 | 0.63 | 1.16 | |||||
| Small cell | 411 | 70.6 | 5.42 | 4.15 | 7.07 | |||||
| Unspecified carcinoma | 19 | 20.4 | 0.45 | 0.24 | 0.84 | |||||
| Neoplasm | 52 | 3.1 | 0.10 | 0.08 | 0.14 | |||||
Abbreviations: CCI score=Charlson comorbidity score; CI=confidence interval; IMD=Index of Multiple Deprivation; NSCLC=non-small cell lung cancer; OR=odds ratio; PS=performance status; SCLC=small cell lung cancer; SEP=socioeconomic position.