Table 2. Multivariate forward stepwise analysis stratified by HIF-1α expression.
| Step | Variable | n | LRFS HR | 95% CI | P | OS HR | 95% CI | P |
|---|---|---|---|---|---|---|---|---|
| 1 |
HIF-1α: treatment |
|
|
|
|
|
|
|
| |
RT alone or HIF-1α<19+CON |
97 |
|
|
|
|
|
|
| |
HIF-1α>19+CON |
36 |
0.49 |
0.27–0.90 |
0.02 |
0.49 |
0.27–0.91 |
0.02 |
| 2 |
Age |
|
|
|
|
|
|
|
| |
<75 |
62 |
|
|
|
|
|
|
| ⩾75 | 71 | 1.65 | 1.06–2.57 | 0.03 | 1.64 | 1.06–2.56 | 0.03 |
Abbreviations: CI=confidence interval; HIF-1α=hypoxia-inducible factor-1α; HR=hazard ratio; LRFS=local relapse-free survival; OS=overall survival.