Table 3. Hazard ratios for 5-year local recurrence-free survival after radiotherapy plus carbogen and nicotinamide compared with radiotherapy alone.
| Variable | HR | 95% CI | P-value |
|---|---|---|---|
|
HIF-1α ⩾19 |
0.48 |
0.26–0.80 |
0.02 |
| HIF-1α <19 |
0.81 |
0.43−1.50 |
0.5 |
|
CAIX >0 |
0.47 |
0.28–0.81 |
0.006 |
| CAIX=0 |
0.81 |
0.43−1.50 |
0.5 |
| GLUT1 ⩾100 |
0.56 |
0.31−1.03 |
0.06 |
| GLUT <100 |
0.62 |
0.32−1.20 |
0.15 |
|
HIF-1α ⩾19+CAIX >0 |
0.38 |
0.18–0.79 |
0.01 |
| HIF-1α <19 or CAIX=0 |
0.74 |
0.43−1.28 |
0.29 |
|
CAIX >0+GLUT1 ⩾0 |
0.47 |
0.23–0.95 |
0.03 |
| CAIX=0 or GLUT1 <100 |
0.64 |
0.35−1.15 |
0.13 |
| HIF-1α ⩾19+GLUT1 ⩾100 |
0.49 |
0.23−1.05 |
0.06 |
| HIF-1α <19 or CAIX=0 |
0.69 |
0.40−1.21 |
0.2 |
|
Necrosis present |
0.46 |
0.29–0.73 |
0.001 |
| Necrosis absent |
1.37 |
0.81−2.30 |
0.24 |
|
Necrosis present+HIF-1α ⩾19 |
0.36 |
0.16–0.79 |
0.01 |
| Necrosis absent or HIF-1α <19 |
0.82 |
0.49−1.38 |
0.45 |
|
Necrosis present+CAIX >0 |
0.47 |
0.25–0.89 |
0.02 |
| Necrosis absent or CAIX=0 |
0.77 |
0.43−1.38 |
0.38 |
|
Necrosis present+GLUT1 ⩾100 |
0.37 |
0.17–0.80 |
0.01 |
| Necrosis absent+GLUT1 <100 | 0.89 | 0.50−1.58 | 0.69 |
Abbreviation: CAIX=carbonic anhydrase IX; CI=confidence interval; GLUT1=glucose transporter 1; HIF-1α=hypoxia-inducible factor-1α; HR=hazard ratio.
Hazard ratios for necrosis were assessed in the 137 patients with available HIF-1α data. Statistically significant differences are highlighted in bold.