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. 2014 Jul 3;111(3):461–469. doi: 10.1038/bjc.2014.352

Table 2. Logistic regression model with a 4 knot restricted cubic spline for the association of provider delay on stage (4 week delay as reference).

 
Model 1
Model 2
Model 3
Model 4
  OR (99% CI) OR (99% CI) OR (99% CI) OR (99% CI)
Provider delay (weeks)
4 1.00 1.00 1.00 1.00
20 0.73 (0.50 1.07) 0.86 (0.57 1.31) 0.84 (0.54 1.32) 0.87 (0.54 1.39)
40 1.29 (0.88 1.88) 1.54 (1.03 2.32) 1.46 (0.95 2.25) 1.46 (0.93 2.31)
60
1.41 (0.92 2.17)
1.72 (1.09 2.72)
1.61 (0.99 2.60)
1.58 (0.96 2.61)
Age
 
0.97 (0.95 0.99)
0.97 (0.95 0.99)
0.97 (0.95 0.99)
Gender
Male   1.32 (0.89 1.95) 1.30 (0.87 1.95) 1.28 (0.85 1.92)
Female
 
1.00
1.00
1.00
Smoking status
Non-smoker   1.00 1.00 1.00
Current smoker   1.13 (0.64 1.98) 1.25 (0.69 2.25) 1.19 (0.66 2.17)
Ex-smoker   1.04 (0.62 1.72) 1.05 (0.62 1.78) 1.06 (0.62 1.81)
Not known
 
1.43 (0.88 2.33)
1.57 (0.95 2.60)
1.52 (0.91 2.53)
Carstairs deprivation quintile
1 (least)   1.00 1.00 1.00
2   0.72 (0.42 1.21) 0.78 (0.45 1.33) 0.77 (0.44 1.33)
3   1.08 (0.63 1.85) 1.18 (0.68 2.06) 1.21 (0.69 2.13)
4   1.16 (0.65 2.08) 1.23 (0.67 2.25) 1.22 (0.66 2.26)
5 (most)
 
0.66 (0.30 1.48)
0.67 (0.30 1.53)
0.65 (0.29 1.50)
Place of presentation
GP surgery   1.00 1.00 1.00
GP home visit   1.07 (0.59 1.94) 1.09 (0.58 2.03) 1.08 (0.58 2.04)
GP out of hours visit   1.85 (0.67 5.08) 2.03 (0.70 5.88) 2.03 (0.69 5.91)
Others   1.21 (0.35 4.11) 1.06 (0.29 3.81) 1.17 (0.32 4.28)
Missing   1.18 (0.40 3.48) 1.11 (0.35 3.52) 1.24 (0.38 4.02)
Charlson Index
 
1.17 (1.07 1.27)
1.18 (1.08 1.30)
1.18 (1.07 1.30)
Grade
Grade I     1.00 1.00
Grade II     6.16 (1.87 20.25) 6.16 (1.85 20.46)
Grade III/IV     14.29 (4.05 50.42) 14.46 (4.07 51.43)
Ungradeable
 
 
6.78 (1.90 24.12)
7.05 (1.96 25.32)
Emergency admission
 
 
0.88 (0.53 1.47)
0.82 (0.49 1.38)
Constipation
 
 
 
1.54 (0.86 2.73)
Rectal bleeding
 
 
 
0.84 (0.52 1.35)
Abdominal Pain
 
 
 
1.16 (0.73 1.84)
Anorexia
 
 
 
1.76 (0.61 5.06)
Weight loss
 
 
 
1.33 (0.65 2.73)
Abdominal Mass       0.83 (0.34 2.03)

Abbreviations: CI=confidence interval; GP=general practitioner; OR=odds ratio.

Values shown are odds ratio (99% confidence interval).

Model 1: unadjusted model for time to treatment with 4 knots.

Model 2: model 1 adding place of presentation, patient age, patient gender, smoking status, deprivation and Charlson index.

Model 3: model 2 adding tumour grade and type of hospital admission.

Model 4: model3 adding constipation, rectal bleeding, abdominal pain, anorexia, weight loss and abdominal mass.