Table 2. Logistic regression model with a 4 knot restricted cubic spline for the association of provider delay on stage (4 week delay as reference).
| |
Model 1 |
Model 2 |
Model 3 |
Model 4 |
|---|---|---|---|---|
| OR (99% CI) | OR (99% CI) | OR (99% CI) | OR (99% CI) | |
|
Provider delay (weeks) | ||||
| 4 | 1.00 | 1.00 | 1.00 | 1.00 |
| 20 | 0.73 (0.50 1.07) | 0.86 (0.57 1.31) | 0.84 (0.54 1.32) | 0.87 (0.54 1.39) |
| 40 | 1.29 (0.88 1.88) | 1.54 (1.03 2.32) | 1.46 (0.95 2.25) | 1.46 (0.93 2.31) |
| 60 |
1.41 (0.92 2.17) |
1.72 (1.09 2.72) |
1.61 (0.99 2.60) |
1.58 (0.96 2.61) |
| Age |
|
0.97 (0.95 0.99) |
0.97 (0.95 0.99) |
0.97 (0.95 0.99) |
|
Gender | ||||
| Male | 1.32 (0.89 1.95) | 1.30 (0.87 1.95) | 1.28 (0.85 1.92) | |
| Female |
|
1.00 |
1.00 |
1.00 |
|
Smoking status | ||||
| Non-smoker | 1.00 | 1.00 | 1.00 | |
| Current smoker | 1.13 (0.64 1.98) | 1.25 (0.69 2.25) | 1.19 (0.66 2.17) | |
| Ex-smoker | 1.04 (0.62 1.72) | 1.05 (0.62 1.78) | 1.06 (0.62 1.81) | |
| Not known |
|
1.43 (0.88 2.33) |
1.57 (0.95 2.60) |
1.52 (0.91 2.53) |
|
Carstairs deprivation quintile | ||||
| 1 (least) | 1.00 | 1.00 | 1.00 | |
| 2 | 0.72 (0.42 1.21) | 0.78 (0.45 1.33) | 0.77 (0.44 1.33) | |
| 3 | 1.08 (0.63 1.85) | 1.18 (0.68 2.06) | 1.21 (0.69 2.13) | |
| 4 | 1.16 (0.65 2.08) | 1.23 (0.67 2.25) | 1.22 (0.66 2.26) | |
| 5 (most) |
|
0.66 (0.30 1.48) |
0.67 (0.30 1.53) |
0.65 (0.29 1.50) |
|
Place of presentation | ||||
| GP surgery | 1.00 | 1.00 | 1.00 | |
| GP home visit | 1.07 (0.59 1.94) | 1.09 (0.58 2.03) | 1.08 (0.58 2.04) | |
| GP out of hours visit | 1.85 (0.67 5.08) | 2.03 (0.70 5.88) | 2.03 (0.69 5.91) | |
| Others | 1.21 (0.35 4.11) | 1.06 (0.29 3.81) | 1.17 (0.32 4.28) | |
| Missing | 1.18 (0.40 3.48) | 1.11 (0.35 3.52) | 1.24 (0.38 4.02) | |
| Charlson Index |
|
1.17 (1.07 1.27) |
1.18 (1.08 1.30) |
1.18 (1.07 1.30) |
|
Grade | ||||
| Grade I | 1.00 | 1.00 | ||
| Grade II | 6.16 (1.87 20.25) | 6.16 (1.85 20.46) | ||
| Grade III/IV | 14.29 (4.05 50.42) | 14.46 (4.07 51.43) | ||
| Ungradeable |
|
|
6.78 (1.90 24.12) |
7.05 (1.96 25.32) |
| Emergency admission |
|
|
0.88 (0.53 1.47) |
0.82 (0.49 1.38) |
| Constipation |
|
|
|
1.54 (0.86 2.73) |
| Rectal bleeding |
|
|
|
0.84 (0.52 1.35) |
| Abdominal Pain |
|
|
|
1.16 (0.73 1.84) |
| Anorexia |
|
|
|
1.76 (0.61 5.06) |
| Weight loss |
|
|
|
1.33 (0.65 2.73) |
| Abdominal Mass | 0.83 (0.34 2.03) | |||
Abbreviations: CI=confidence interval; GP=general practitioner; OR=odds ratio.
Values shown are odds ratio (99% confidence interval).
Model 1: unadjusted model for time to treatment with 4 knots.
Model 2: model 1 adding place of presentation, patient age, patient gender, smoking status, deprivation and Charlson index.
Model 3: model 2 adding tumour grade and type of hospital admission.
Model 4: model3 adding constipation, rectal bleeding, abdominal pain, anorexia, weight loss and abdominal mass.