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. 2014 Jul 9;3(7):e123. doi: 10.1038/psp.2014.21

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Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics

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Comparison between DILIsym v2C and data reported in James et al.³⁰ James et al. report their data in terms of histology grade, which was assumed to map to ~25, 50, and 75% hepatocyte loss for grades I, II, and III, respectively. The red line represents the behavior of the baseline human model; the red dots represent individuals in the small human SimPops.