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. Author manuscript; available in PMC: 2014 Aug 4.
Published in final edited form as: Annu Rev Med. 2013 Nov 20;65:333–347. doi: 10.1146/annurev-med-060512-150254

Figure 1.

Figure 1

Antibodies can bind to surface antigens expressed on tumor cells. Chimeric antigen receptors (CARs) have a single-chain antibody fragment (scFv), expressed in tandem with signaling elements derived from the T cell receptor (TCR) and costimulatory domains such as 4-1BB and CD28.