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. 2014 Aug;24(8):1251–1259. doi: 10.1101/gr.172809.114

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© 2014 Friedli et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — Global up-regulation of EREs during reprogramming. qPCR quantification of transcripts from indicated murine (A–D) and human (E–H) EREs during reprogramming of MEFs and cord blood CD34⁺ cells, respectively. Expression levels are indicated for parental cells (gray dots), cells transduced with an SFFV-GFP control vector (green dots), OKS-induced reprogramming time points (blue dots), individual iPS clones (orange dots), and ES cells (red dots). For the smoothing pattern across OKS-induced reprogramming time points, we computed a locally weighted polynomial regression (LOESS) with a 95% confidence interval.