Table 3.

Logistic regression for variables predictive of clozapine response

Variable	Research setting (n = 85)				Routine clinical practice (n = 223)
	Odds Ratio	95% CI	χ2 (df = 1)	P-value	Odds ratio	95% CI	χ2 (df = 1)	P-value
Age (Years)	0.90	0.82–0.99	4.28	0.04a	0.99	0.95–1.04	0.08	0.77
Race: White	1.80	0.41–7.88	0.6	0.44	1.00	0.49–2.05	< 0.001	0.99
Male	0.23	0.06–0.92	4.33	0.04b	1.48	0.64–3.42	0.82	0.37
Baseline positive symptoms	0.91	0.74–1.13	0.71	0.40	1.00	0.91–1.09	0.01	0.92
Baseline negative symptoms	0.63	0.23–1.74	0.81	0.41	0.95	0.70–1.29	0.12	0.99
Baseline hostility	1.15	0.90–1.47	1.17	0.28	0.99	0.86–1.10	0.07	0.79
Baseline anxiety/Depression	0.87	0.72–1.05	2.19	0.14	1.04	0.96–1.14	0.91	0.34
Baseline activation	0.90	0.67–1.19	0.57	0.45	0.90	0.81–1.00	3.56	0.06c

^aYounger patients more likely to respond

^bFemales more likely to respond

^cTrend for higher activation scores more likely to respond