TABLE 1. Pharmacological Potencies, Toxicities and In Vitro Therapeutic Indices of Nrf2 Inducers in H4IIE-ARE8L Cells.

	CDa (μM)	LC50b (μM)	Therapeutic indexc
TP-225	0.0005 ± 0.0001	1.6 ± 0.2	3448.3 ± 698.2
BARD	0.001 ± 0.0001	2.1 ± 0.5	1818.1 ± 356.3
TP-162	0.02 ± 0.009	18.4 ± 4.6	1397.7 ± 415.1
TP-151	0.01 ± 0.004	16.3 ± 3.7	1373.3 ± 201.5
TP-319	0.005 ± 0.001	1.9 ± 0.2	417.7 ± 72.1
SUL	0.4 ± 0.1	51.9 ± 2.6	140.6 ± 38.4
TP-222	0.2 ± 0.02	7.2 ± 0.3	33.5 ± 2.1
DMF	20.5 ± 8.7	184.4 ± 4.8	10.0 ± 3.7
TP-198	1.6 ± 0.6	8.1 ± 1.4	5.5 ± 1.4
TP-233	4.6 ± 2.1	10.4 ± 2.6	2.6 ± 1.4
TP-72	29.1 ± 2.7	N.D.d	N.D.d

^aConcentration that provokes a twofold increase in ARE8L reporter transgene activity.

^bConcentration that provokes a twofold decrease in cellular ATP content.

^cRatio of LC50 divided by CD.

^dNot determined, due to lack of ATP depletion at the highest possible concentration (100μM).