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. Author manuscript; available in PMC: 2014 Aug 4.
Published in final edited form as: JACC Heart Fail. 2013 Jun 3;1(3):207–212. doi: 10.1016/j.jchf.2013.03.001

Figure 1.

Figure 1

Schematic of proBNP1–108 and two of its derivatives, NTproBNP1–76 and BNP1–32 (which is proBNP77–108). Two putative enzymes involved in proBNP cleavage are corin and furin. The specific proBNP1–108 assay (Bio-Rad, Hercules, CA, USA) uses a capture antibody directed against the hinge region, i.e. region in which proBNP1–108 is cleaved into bioactive BNP1–32 and inactive NTproBNP1–76. There is a monoclonal detection antibody directed against BNP1–32 epitopes. Thus, the proBNP1–108 assay only detects uncleaved proBNP forms.