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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2014 Jan;73(1):39–49. doi: 10.1097/NEN.0000000000000023

Table 1. In Vivo Diffusion Tensor Imaging Parameter Values from White and Gray Matter Regions of the Brain of Wild-Type and Mucopolysaccharidosis VII Model Mice.

Region White matter
FA MD CL CP CS
AC Wild-type 0.50 ± 0.05 0.62 ± 0.11 0.42 ± 0.06 0.20 ± 0.06 0.31 ± 0.07
MPS VII 0.40 ± 0.08 0.64 ± 0.07 0.38 ± 0.10 0.16 ± 0.04 0.46 ± 0.07
p value 0.050* 0.748 0.280 0.224 0.008*
CC Wild-type 0.55 ± 0.05 0.59 ± 0.09 0.52 ± 0.05 0.16 ± 0.05 0.32 ± 0.06
MPS VII 0.48 ± 0.05 0.59 ± 0.09 0.48 ± 0.04 0.14 ± 0.03 0.39 ± 0.06
p value 0.024* 0.921 0.124 0.487 0.089
EC Wild-type 0.35 ± 0.05 0.60 ± 0.10 0.25 ± 0.07 0.27 ± 0.04 0.48 ± 0.06
MPS VII 0.30 ± 0.04 0.59 ± 0.11 0.20 ± 0.05 0.28 ± 0.06 0.52 ± 0.06
p value 0.025* 0.830 0.085 0.624 0.140
IC Wild-type 0.49 ± 0.09 0.63 ± 0.10 0.48 ± 0.06 0.17 ± 0.05 0.37 ± 0.08
MPS VII 0.44 ± 0.09 0.62 ± 0.10 0.41 ± 0.09 0.17 ± 0.04 0.42 ± 0.09
p value 0.177 0.758 0.176 0.935 0.166
Gray matter
Cereb Wild-type 0.21 ± 0.04 0.61 ± 0.08 0.17 ± 0.06 0.17 ± 0.03 0.66 ± 0.06
MPS VII 0.21 ± 0.03 0.54 ± 0.09 0.21 ± 0.04 0.14 ± 0.05 0.66 ± 0.05
p value 0.788 0.102 0.171 0.079 0.971
HC Wild-type 0.21 ± 0.03 0.64 ± 0.11 0.19 ± 0.05 0.14 ± 0.04 0.68 ± 0.05
MPS VII 0.18 ± 0.02 0.67 ± 0.16 0.15 ± 0.03 0.14 ± 0.02 0.66 ± 0.18
p value 0.035* 0.540 0.043* 0.843 0.741
Cpu Wild-type 0.19 ± 0.05 0.73 ± 0.22 0.16 ± 0.03 0.15 ± 0.05 0.68 ± 0.06
MPS VII 0.19 ± 0.05 0.69 ± 0.14 0.16 ± 0.06 0.16 ± 0.02 0.68 ± 0.06
p value 0.954 0.637 0.989 0.901 0.992

FA = Fractional anisotropy, MD = Mean diffusivity (x10-3mm2/s), CL = Linear anisotropy, CP = Planner anisotropy, CS = Spherical anisotropy. AC =Anterior-commissure, Cereb = Cerebral cortex, CC = Corpus callosum, Cpu = Caudate putamen, HC = Hippocampus, EC = External capsule, IC =Internal capsule.

*

Asterisk represents significant differences between mucopolysaccharidosis (MPS) VII and wild type littermates.