Table 1. In Vivo Diffusion Tensor Imaging Parameter Values from White and Gray Matter Regions of the Brain of Wild-Type and Mucopolysaccharidosis VII Model Mice.
Region | White matter | |||||
---|---|---|---|---|---|---|
FA | MD | CL | CP | CS | ||
AC | Wild-type | 0.50 ± 0.05 | 0.62 ± 0.11 | 0.42 ± 0.06 | 0.20 ± 0.06 | 0.31 ± 0.07 |
MPS VII | 0.40 ± 0.08 | 0.64 ± 0.07 | 0.38 ± 0.10 | 0.16 ± 0.04 | 0.46 ± 0.07 | |
p value | 0.050* | 0.748 | 0.280 | 0.224 | 0.008* | |
CC | Wild-type | 0.55 ± 0.05 | 0.59 ± 0.09 | 0.52 ± 0.05 | 0.16 ± 0.05 | 0.32 ± 0.06 |
MPS VII | 0.48 ± 0.05 | 0.59 ± 0.09 | 0.48 ± 0.04 | 0.14 ± 0.03 | 0.39 ± 0.06 | |
p value | 0.024* | 0.921 | 0.124 | 0.487 | 0.089 | |
EC | Wild-type | 0.35 ± 0.05 | 0.60 ± 0.10 | 0.25 ± 0.07 | 0.27 ± 0.04 | 0.48 ± 0.06 |
MPS VII | 0.30 ± 0.04 | 0.59 ± 0.11 | 0.20 ± 0.05 | 0.28 ± 0.06 | 0.52 ± 0.06 | |
p value | 0.025* | 0.830 | 0.085 | 0.624 | 0.140 | |
IC | Wild-type | 0.49 ± 0.09 | 0.63 ± 0.10 | 0.48 ± 0.06 | 0.17 ± 0.05 | 0.37 ± 0.08 |
MPS VII | 0.44 ± 0.09 | 0.62 ± 0.10 | 0.41 ± 0.09 | 0.17 ± 0.04 | 0.42 ± 0.09 | |
p value | 0.177 | 0.758 | 0.176 | 0.935 | 0.166 | |
Gray matter | ||||||
Cereb | Wild-type | 0.21 ± 0.04 | 0.61 ± 0.08 | 0.17 ± 0.06 | 0.17 ± 0.03 | 0.66 ± 0.06 |
MPS VII | 0.21 ± 0.03 | 0.54 ± 0.09 | 0.21 ± 0.04 | 0.14 ± 0.05 | 0.66 ± 0.05 | |
p value | 0.788 | 0.102 | 0.171 | 0.079 | 0.971 | |
HC | Wild-type | 0.21 ± 0.03 | 0.64 ± 0.11 | 0.19 ± 0.05 | 0.14 ± 0.04 | 0.68 ± 0.05 |
MPS VII | 0.18 ± 0.02 | 0.67 ± 0.16 | 0.15 ± 0.03 | 0.14 ± 0.02 | 0.66 ± 0.18 | |
p value | 0.035* | 0.540 | 0.043* | 0.843 | 0.741 | |
Cpu | Wild-type | 0.19 ± 0.05 | 0.73 ± 0.22 | 0.16 ± 0.03 | 0.15 ± 0.05 | 0.68 ± 0.06 |
MPS VII | 0.19 ± 0.05 | 0.69 ± 0.14 | 0.16 ± 0.06 | 0.16 ± 0.02 | 0.68 ± 0.06 | |
p value | 0.954 | 0.637 | 0.989 | 0.901 | 0.992 |
FA = Fractional anisotropy, MD = Mean diffusivity (x10-3mm2/s), CL = Linear anisotropy, CP = Planner anisotropy, CS = Spherical anisotropy. AC =Anterior-commissure, Cereb = Cerebral cortex, CC = Corpus callosum, Cpu = Caudate putamen, HC = Hippocampus, EC = External capsule, IC =Internal capsule.
Asterisk represents significant differences between mucopolysaccharidosis (MPS) VII and wild type littermates.