Table 2. Ex Vivo Diffusion Tensor Imaging Parameter Values from White and Gray Matter Regions of the Brain of Wild-Type and Mucopolysaccharidosis VII Model Mice.

Regions		White matter
		FA	MD	CL	CP	CS
AC	Wild-type	0.75 ± 0.08	0.21 ± 0.05	0.70 ± 0.09	0.15 ± 0.06	0.13 ± 0.03
	MPS VII	0.65 ± 0.01	0.28 ± 0.04	0.64 ± 0.03	0.15 ± 0.04	0.21 ± 0.03
	p-value	0.024*	0.048*	0.236	0.903	0.005*
CC	Wild-type	0.77 ± 0.06	0.23 ± 0.03	0.70 ± 0.11	0.32 ± 0.25	0.14 ± 0.06
	MPS VII	0.69 ± 0.05	0.31 ± 0.06	0.63 ± 0.08	0.20 ± 0.09	0.18 ± 0.06
	p-value	0.047*	0.031*	0.245	0.348	0.275
EC	Wild-type	0.51 ± 0.07	0.32 ± 0.01	0.30 ± 0.07	0.40 ± 0.06	0.30 ± 0.08
	MPS VII	0.39 ± 0.05	0.36 ± 0.11	0.27 ± 0.08	0.32 ± 0.06	0.14 ± 0.08
	p-value	0.016*	0.624	0.601	0.045*	0.048*
IC	Wild-type	0.59 ± 0.06	0.30 ± 0.08	0.59 ± 0.12	0.17 ± 0.05	0.24 ± 0.07
	MPS VII	0.58 ± 0.07	0.35 ± 0.14	0.56 ± 0.09	0.15 ± 0.02	0.30 ± 0.08
	p-value	0.980	0.451	0.714	0.358	0.296
Gray matter
Cereb	Wild-type	0.20 ± 0.05	0.41 ± 0.14	0.14 ± 0.02	0.16 ± 0.05	0.70 ± 0.05
	MPS VII	0.16 ± 0.01	0.41 ± 0.15	0.15 ± 0.02	0.12 ± 0.01	0.73 ± 0.01
	p-value	0.094	0.993	0.681	0.129	0.156
HC	Wild-type	0.27 ± 0.03	0.39 ± 0.14	0.23 ± 0.04	0.17 ± 0.04	0.60 ± 0.06
	MPS VII	0.25 ± 0.04	0.43 ± 0.16	0.24 ± 0.04	0.17 ± 0.04	0.63 ± 0.06
	p-value	0.494	0.692	0.422	0.837	0.443
Cpu	Wild-type	0.22 ± 0.05	0.50 ± 0.26	0.18 ± 0.06	0.15 ± 0.01	0.67 ± 0.06
	MPS VII	0.19 ± 0.07	0.51 ± 0.31	0.20 ± 0.11	0.13 ± 0.02	0.67 ± 0.13
	p-value	0.542	0.712	0.752	0.140	0.988

FA = Fractional anisotropy, MD = Mean diffusivity (x10^-3mm²/s), CL = Linear anisotropy, CP = Planner anisotropy, CS = Spherical anisotropy. AC = Anterior-commissure, Cereb = Cerebral cortex, CC = Corpus callosum, Cpu = Caudate putamen, HC = Hippocampus, EC = External capsule, IC = Internal capsule.

^*Asterisk indicates significant differences between mucopolysaccharidosis (MPS) VII and wild type littermates.