Table 3.
Interactions of IgE measures with age groups and length of time until case diagnosis
| Age | Interaction p | ||
|---|---|---|---|
| <65 | ≥65 | ||
| Total IgE | |||
| Cases/ Controls | 130/247 | 151/295 | |
| Normal | 1 | 1 | 0.003 |
| Borderline | 0.45 (0.26-0.77) | 1.43 (0.88-2.32) | |
| Elevated | 0.71 (0.41-1.24) | 1.98 (1.16-3.37) | |
| IgE to respiratory allergens | |||
| Cases/ Controls | 130/247 | 153/295 | |
| Negative | 1 | 1 | 0.25 |
| Positive | 0.94 (0.58-1.53) | 1.39 (0.89-2.18) | |
| IgE to food allergens | |||
| Cases/ Controls | 130/247 | 153/294 | |
| Negative | 1 | 1 | 0.03 |
| Positive | 0.80 (0.34-1.91) | 2.83 (1.29-6.20) | |
| Years between enrollment and diagnosis | ||||
|---|---|---|---|---|
| 0-5 Years | 6-9 Years | 10-15 Years | ||
| Total IgE | ||||
| Cases/ Controls | 98/188 | 105/200 | 78/154 | |
| Normal | 1 | 1 | 1 | |
| Borderline | 0.64 (0.35-1.17) | 1.14 (0.64-2.01) | 0.79 (0.40-1.55) | 0.63 |
| Elevated | 1.26 (0.66-2.41) | 1.45 (0.77-2.76) | 0.96 (0.49-1.91) | |
| IgE to respiratory allergens | ||||
| Cases/ Controls | 98/188 | 107/200 | 78/154 | |
| Negative | 1 | 1 | 1 | 0.36 |
| Positive | 1.37 (0.76-2.46) | 1.35 (0.80-2.28) | 0.80 (0.43-1.48) | |
| IgE to food allergens | ||||
| Cases/ Controls | 98/188 | 107/200 | 78/153 | |
| Negative | 1 | 1 | 1 | 0.98 |
| Positive | 1.47 (0.53-4.07) | 1.56 (0.64-3.81) | 1.68 (0.63-4.48) | |
Stratum-specific odds ratios estimated using conditional logistic regression models with interaction terms and adjusting for smoking (for total IgE and IgE to respiratory allergens; never, former quit >15 years ago, former quit <15 years ago, current) or study center (for IgE to food allergens)