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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: J Pediatr. 2014 Feb 14;164(6):1339–45.e5. doi: 10.1016/j.jpeds.2013.12.035

Table 5.

Characteristics of In-hospital Formula Use§ and Corresponding Odds Ratios of Not Fully Breastfeeding Days 30–60 and Breastfeeding Cessation By Day 60

Variable Category Number in category (%)# Not Fully Breastfeeding Days 30–60* Breastfeeding Cessation By Day 60**
% OR [95%CI] Adjusted OR& [95%CI] P-value£ % OR [95%CI] Adjusted OR& [95%CI] P-value£
Exclusive breastfeeding in-hospital (H-EBF)@ 210 (54%) 36.7% Referent Referent n/a 10.5% Referent Referent n/a
Any in-hospital formula use 183 (47%) 67.8% 3.6 (2.4,5.5) 3.9 (2.2,6.5) <0.0001 32.8% 4.2 (2.4,7.1) 4.4 (2.2,8.7) <0.0001
Characteristics of In-hospital Formula Use
Volume (0–72 h) 0.016 0.10
None 210 (54%) 36.7% Referent Referent n/a 10.5% Referent Referent n/a
1–30 mL 48 (12%) 56.2% 2.2 (1.2,4.2) 1.9 (0.95,4.0) 18.8% 2.0 (0.84,4.6) 2.0 (0.77,5.2)
31–60 mL 26 (7%) 76.9% 5.8 (2.2,15.0) 7.1 (2.5,20.0) 38.5% 5.3 (2.2,13.2) 7.3 (2.5,21.6)
61–180 mL 58 (15%) 65.5% 3.3 (1.8,6.0) 4.5 (2.2,9.6) 31.0 % 3.8 (1.9,7.8) 5.7 (2.3,14.1)
>180 mL 46 (12%) 82.6% 8.2 (3.6,18.5) 10.5 (3.9,28.5) 50.0% 8.5 (4.1,17.7) 8.7 (3.2,23.2)
Number of formula feeds 0–72 h 0.002 0.003
1–3 68 (17%) 57.4% 2.3 (1.3, 4.1) 2.3 (1.2, 4.3) 20.6% 2.2 (1.1, 4.6) 2.2 (0.9, 5.1)
4–8 55 (14%) 61.8% 2.8 (1.5, 5.2) 4.1 (1.9, 8.7) 25.5% 2.9 (1.4, 6.2) 5.6 (2.1, 15)
9–31 60 (15%) 85% 9.8 (4.6, 21) 14 (5.2, 35) 53.3% 9.8 (5.0, 19) 12 (4.7, 30)
Method of feedingΣ
Bottle - yes 115 (39%) 74.8% 5.1 (3.1,8.5) 5.3 (2.9,9.8) 0.011Ω 40% 5.7 (3.2,10.2) 5.3 (2.6,10.9) 0.068 Ω
Method(s) did not include bottle use 56 (15%) 53.6% 2.0 (1.1,3.6) 2.1 (1.1,4.4) 19.6% 2.1 (0.9,4.6) 2.6 (1.01,6.7)
Cup - yes 27 (7%) 66.7% 3.4 (1.5,8.1) 4.8 (1.8,13.1) 0.57 Ω 33.3% 4.3 (1.7,10.7) 5.9 (2.0,17.9) 0.57 Ω
SNS¥ - yes 27 (7%) 66.7% 3.4 (1.5,8.1) 5.9 (2.2,15.5) 0.18 Ω 22.2% 2.4 (0.9,6.7) 4.6 (1.4,15.1) 0.97 Ω
Syringe - yes 86 (23%) 73.3% 4.7 (2.7,8.2) 5.7 (2.9,11.1) 0.042 Ω 32.6% 4.1 (2.2,7.8) 5.3 (2.4,11.8) 0.31 Ω
Finger- yes 11(3%) 72.7% 4.6 (1.2,17.9) 8.2 (1.8, 36.6) 0.21 Ω 27.3% 3.2 (0.8,13.0) 8.5 (1.7,42.1) 0.55 Ω
#

Percent is of all infants with follow-up data, n=393; n/a = not applicable; BF= breastfeeding; EBF= exclusive breastfeeding;

*

51.1% of total received supplemental formula days 30–60;

**

20.9% of total experienced breastfeeding cessation before day 60;

OR [95%CI] =Odds ratio [95% confidence interval]; Referent group for all odds ratios is exclusive breastfeeding in-hospital;

£

p-value for adjusted odds ratio;

&

Adjusted for maternal demographics (age, education, type of insurance), length of hospital stay and prenatally assessed Infant Feeding Intention rank;

£

P-value is for difference among categories of formula use;

P-value for trend test among H-formula users;

¥

Supplemental nursing system;

Σ

Multiple supplementation methods could be used;

Ω

p-value is for supplemented infants with vs. without that method of feeding;

No significant differences noted by timing of first in-hospital formula use, whether breastfed prior to in-hospital formula use or by whom recommended formula use (physican, nurse, lactation consultant or maternal preference).