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. Author manuscript; available in PMC: 2014 Aug 4.
Published in final edited form as: Annu Rev Immunol. 2013 Jan 16;31:635–674. doi: 10.1146/annurev-immunol-032712-095921

Table 3.

The history of HHLS mice

Strain Acronym T/B cell deficiency NK cell deficiency Phagocytosis tolerance Features Reference(s)
1988 CB17-Scid Hu-PBL-SCID Scid – – Transplantation of PBL 22
1988 CB17-Scid SCID-hu Scid – – Transplantation of fetal tissues 23
1992 CB17-Scid Hu-SRC-SCID Scid – – Transplantation of HSCs 55
1995 NOD-Scid NOD-Scid Scid Reduced function NOD Sirpa Increased phagocytic tolerance 57, 205, 206
2002 NOD/Shi-scid Il2rg–/– NOG Scid Truncated IL-2Rγ NOD Sirpa No NK cells and phagocytic tolerance 31
2004 BALB/c-Rag2–/– Il2rg–/– BRG Rag2–/– Il2rg–/– – No NK cells transplantation in newborn 28
2005 NOD/LtSz-scid Il2rg–/– NSG Scid Il2rg–/– NOD Sirpa No NK cells and phagocytic tolerance 32, 174
2006 NOD-Scid BLT Scid – NOD Sirpa T cell development in human thymic tissue 61, 62
2011 hSIRPAtg Rag2–/– Il2rg–/– SRG Rag2–/– Il2rg–/– Human SIRPA Similar to NOG/NSG 35

Abbreviations: BLT, bone-liver-thymus; HSC, hematopoietic stem cell; NK, natural killer; NOD, nonobese diabetic; PBL, peripheral blood leukocytes; Scid, severe combined immunodeficiency; SRC, Scid-repopulating cell; – indicates no deficiency or no tolerance.